Facile synthesis of 2',3'-unsaturated nucleosides from 2-deoxyribose

被引：10

作者：

Sujino, K ^{[1
]}

Yoshida, T ^{[1
]}

Sugimura, H ^{[1
]}

机构：

[1] NOGUCHI INST,ITABASHI KU,TOKYO 173,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 34期

关键词：

D O I：

10.1016/0040-4039(96)01293-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward approach for the synthesis of 2',3'-unsaturated nucleosides starting from 2-deoxyribose is described. This novel route involves two new methods; (1) preparation of 2-deoxy-1-thioribofuranoside by direct condensation of 2-deoxyribose and thiophenol, (2) formation of the nucleoside skeleton by the direct coupling of 2,3-unsaturated 1-thiopentofuranoside with pyrimidine bases. Copyright (C) 1996 Elsevier Science Ltd

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页码：6133 / 6136

页数：4

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