Access to chiral tertiary amines via the iridium-catalyzed asymmetric hydrogenation of enamines

被引：35

作者：

Cheruku, Pradeep ^{[1
]}

Church, Tamara L. ^{[1
]}

Trifonova, Anna ^{[1
]}

Wartmann, Thomas ^{[1
]}

Andersson, Pher G. ^{[1
]}

机构：

[1] Uppsala Univ, Dept Biochem & Organ Chem, S-75123 Uppsala, Sweden

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 51期

基金：

瑞典研究理事会;

关键词：

Asymmetric catalysis; Hydrogenation; Enamines; Chiral tertiary amines;

D O I：

10.1016/j.tetlet.2008.10.035

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric hydrogenation of N,N-dialkyl and N-alkyl-N-aryl enamines to chiral tertiary amines was studied. All the N,P-ligated iridium complexes investigated were active catalysts for the reaction, but only those with bicycle-supported oxazoline-phosphine ligands gave reasonable stereoinduction. The best catalyst produced a range of chiral tertiary amines in up to 87% ee. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：7290 / 7293

页数：4

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