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Diversity of CRISPR-Cas immune systems and molecular machines

被引：64
作者：
Barrangou, Rodolphe [1 ]
机构：
[1] N Carolina State Univ, Dept Food Bioproc & Nutr Sci, Raleigh, NC 27695 USA
来源：
GENOME BIOLOGY | 2015年 / 16卷
关键词：
GUIDED SURVEILLANCE COMPLEX; IN-VITRO RECONSTITUTION; R-LOOP FORMATION; CRYSTAL-STRUCTURE; RNA CLEAVAGE; CMR COMPLEX; ACQUIRED-RESISTANCE; SPACER ACQUISITION; ESCHERICHIA-COLI; DNA INTERFERENCE;
D O I：
10.1186/s13059-015-0816-9
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 [微生物学]; 090105 [作物生产系统与生态工程];
摘要：
Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.
引用
收藏
页数：11
相关论文
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