Curcumin and 5-Fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia

被引：93

作者：

Balasubramanian, Sivakumar ^{[1
]}

Girija, Aswathy Ravindran ^{[1
]}

Nagaoka, Yutaka ^{[1
]}

Iwai, Seiki ^{[1
]}

Suzuki, Masashi ^{[1
]}

Kizhikkilot, Venugopal ^{[2
]}

Yoshida, Yasuhiko ^{[1
]}

Maekawa, Toru ^{[1
]}

Nair, Sakthikumar Dasappan ^{[1
]}

机构：

[1] Toyo Univ, Bio Nano Elect Res Ctr, Grad Sch Interdisciplinary New Sci, Kawagoe, Saitama, Japan

[2] Sooriya Hosp, Dept Resp Med, Madras, Tamil Nadu, India

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2014年 / 9卷

关键词：

nanotechnology; curcumin; 5FU; folate; transferrin; PLGA nanoparticle; magnetic hyperthermia; SUPERPARAMAGNETIC IRON-OXIDE; IN-VITRO; LOADED NANOPARTICLES; PLGA NANOPARTICLES; CELL-DEATH; APOPTOSIS; VIVO; TUMORS; MODEL;

D O I：

10.2147/IJN.S49882

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The efficient targeting and therapeutic efficacy of a combination of drugs (curcumin and 5-Fluorouracil [5FU]) and magnetic nanoparticles encapsulated poly(D, L-lactic-co-glycolic acid) nanoparticles, functionalized with two cancer-specific ligands are discussed in our work. This multifunctional, highly specific nanoconjugate resulted in the superior uptake of nanoparticles by cancer cells. Upon magnetic hyperthermia, we could harness the advantages of incorporating magnetic nanoparticles that synergistically acted with the drugs to destroy cancer cells within a very short period of time. The remarkable multimodal efficacy attained by this therapeutic nanoformulation offers the potential for targeting, imaging, and treatment of cancer within a short period of time (120 minutes) by initiating early and late apoptosis.

引用

页码：437 / 459

页数：23

共 69 条

[21] Epithelial internalization of superparamagnetic nanoparticles and response to external magnetic field [J].

Dormer, K ;

Seeney, C ;

Lewelling, K ;

Lian, GD ;

Gibson, D ;

Johnson, M .

BIOMATERIALS, 2005, 26 (14) :2061-2072

[22] PLGA nanoparticles of different surface properties: Preparation and evaluation of their body distribution [J].

Esmaeili, Farnaz ;

Ghahremani, Mohammad Hossein ;

Esmaeili, Behnaz ;

Khoshayand, Mohammad Reza ;

Atyabi, Fatemeh ;

Dinarvand, Rassoul .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 349 (1-2) :249-255

[23] Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia [J].

Fortin, Jean-Paul ;

Wilhelm, Claire ;

Servais, Jacques ;

Menager, Christine ;

Bacri, Jean-Claude ;

Gazeau, Florence .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (09) :2628-2635

[24] Acute and Long-Term Effects of Hyperthermia in B16-F10 Melanoma Cells [J].

Garcia, Monica Pereira ;

Tinoco Cavalheiro, Jose Roberto ;

Fernandes, Maria Helena .

PLOS ONE, 2012, 7 (04)

[25] Curcumin as "Curecumin":: From kitchen to clinic [J].

Goel, Ajay ;

Kunnumakkara, Ajaikumar B. ;

Aggarwal, Bharat B. .

BIOCHEMICAL PHARMACOLOGY, 2008, 75 (04) :787-809

[26] The Potential Role of Curcumin in Patients with Monoclonal Gammopathy of Undefined Significance-Its Effect on Paraproteinemia and the Urinary N-Telopeptide of Type I Collagen Bone Turnover Marker [J].

Golombick, Terry ;

Diamond, Terrence H. ;

Badmaev, Vladimir ;

Manoharan, Arumugam ;

Ramakrishna, Rajeev .

CLINICAL CANCER RESEARCH, 2009, 15 (18) :5917-5922

[27] Self-Assembled Hydrogel Nanoparticles for Drug Delivery Applications [J].

Goncalves, Catarina ;

Pereira, Paula ;

Gama, Miguel .

MATERIALS, 2010, 3 (02) :1420-1460

[28] INTRACELLULAR HYPERTHERMIA - BIOPHYSICAL APPROACH TO CANCER-TREATMENT VIA INTRACELLULAR TEMPERATURE AND BIOPHYSICAL ALTERATIONS [J].

GORDON, RT ;

HINES, JR ;

GORDON, D .

MEDICAL HYPOTHESES, 1979, 5 (01) :83-102

[29] Magnetically modulated therapeutic systems [J].

Häfeli, UO .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2004, 277 (1-2) :19-24

[30] Biomedical applications of maghemite ferrofluid [J].

Halbreich, A ;

Roger, J ;

Pons, JN ;

Geldwerth, D ;

Da Silva, MF ;

Roudier, M ;

Bacri, JC .

BIOCHIMIE, 1998, 80 (5-6) :379-390

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