Curcumin and 5-Fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia

被引：93

作者：

Balasubramanian, Sivakumar ^{[1
]}

Girija, Aswathy Ravindran ^{[1
]}

Nagaoka, Yutaka ^{[1
]}

Iwai, Seiki ^{[1
]}

Suzuki, Masashi ^{[1
]}

Kizhikkilot, Venugopal ^{[2
]}

Yoshida, Yasuhiko ^{[1
]}

Maekawa, Toru ^{[1
]}

Nair, Sakthikumar Dasappan ^{[1
]}

机构：

[1] Toyo Univ, Bio Nano Elect Res Ctr, Grad Sch Interdisciplinary New Sci, Kawagoe, Saitama, Japan

[2] Sooriya Hosp, Dept Resp Med, Madras, Tamil Nadu, India

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2014年 / 9卷

关键词：

nanotechnology; curcumin; 5FU; folate; transferrin; PLGA nanoparticle; magnetic hyperthermia; SUPERPARAMAGNETIC IRON-OXIDE; IN-VITRO; LOADED NANOPARTICLES; PLGA NANOPARTICLES; CELL-DEATH; APOPTOSIS; VIVO; TUMORS; MODEL;

D O I：

10.2147/IJN.S49882

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The efficient targeting and therapeutic efficacy of a combination of drugs (curcumin and 5-Fluorouracil [5FU]) and magnetic nanoparticles encapsulated poly(D, L-lactic-co-glycolic acid) nanoparticles, functionalized with two cancer-specific ligands are discussed in our work. This multifunctional, highly specific nanoconjugate resulted in the superior uptake of nanoparticles by cancer cells. Upon magnetic hyperthermia, we could harness the advantages of incorporating magnetic nanoparticles that synergistically acted with the drugs to destroy cancer cells within a very short period of time. The remarkable multimodal efficacy attained by this therapeutic nanoformulation offers the potential for targeting, imaging, and treatment of cancer within a short period of time (120 minutes) by initiating early and late apoptosis.

引用

页码：437 / 459

页数：23

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