C-H activation as a strategic reaction: Enantioselective synthesis of 4-substituted indoles

被引：60

作者：

Davies, HML ^{[1
]}

Manning, JR ^{[1
]}

机构：

[1] SUNY Buffalo, Univ Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 04期

关键词：

D O I：

10.1021/ja057768+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method is described for the asymmetric synthesis of 4-substituted indoles from the Rh2(S-DOSP)4-catalyzed decomposition of vinyldiazoacetates in the presence of N-Boc-4-acetoxy-6,7-dihydroindole. The reaction proceeds via a combined C-H activation/Cope rearrangement-elimination mechanism resulting in good yields and very high asymmetric induction. Copyright © 2006 American Chemical Society.

引用

页码：1060 / 1061

页数：2

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