Acidic polysaccharide from Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion

被引：57

作者：

Han, SB ^{[1
]}

Lee, CW ^{[1
]}

Kang, JS ^{[1
]}

Yoon, YD ^{[1
]}

Lee, KH ^{[1
]}

Lee, K ^{[1
]}

Park, SK ^{[1
]}

Kim, HM ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2006年 / 6卷 / 04期

关键词：

Phellinus linteus; metastasis; invasion; adhesion;

D O I：

10.1016/j.intimp.2005.10.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The acidic polysaccharide (PL) from Phellinus linteus is an immunostimulator that has therapeutic activity against cancers. Here, we show that PL markedly inhibits melanoma cell metastasis in mice, and report that PL directly inhibits cancer cell adhesion to and invasion through the extracellular matrix, but that it has no direct effect on cancer cell growth. In addition, we found that PL increased macrophage NO production. These results suggest that PL has two antimetastatic functions, i.e., it acts as an immunopotentiator and as a direct inhibitor of cancer cell adhesion. (c) 2005 Elsevier B.V All rights reserved.

引用

页码：697 / 702

页数：6

共 26 条

[11] Mechanism by which orally administered β-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models [J].

Hong, F ;

Yan, J ;

Baran, JT ;

Allendorf, DJ ;

Hansen, RD ;

Ostroff, GR ;

Xing, PX ;

Cheung, NKV ;

Ross, GD .

JOURNAL OF IMMUNOLOGY, 2004, 173 (02) :797-806

[12]

Hong F, 2003, CANCER RES, V63, P9023

[13] Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell [J].

Hu, HB ;

Ahn, NS ;

Yang, XL ;

Lee, YS ;

Kang, KS .

INTERNATIONAL JOURNAL OF CANCER, 2002, 102 (03) :250-253

[14]

Kato R, 2002, CLIN CANCER RES, V8, P2455

[15] Proteoglycan isolated from Phellinus linteus inhibits tumor growth through mechanisms leading to an activation of CD11c+CD8+ DC and type I helper T cell-dominant immune state [J].

Kim, GY ;

Oh, WK ;

Shin, BC ;

Shin, YI ;

Park, YC ;

Ahn, SC ;

Lee, JD ;

Bae, YS ;

Kwak, JY ;

Park, YM .

FEBS LETTERS, 2004, 576 (03) :391-400

[16] Proteoglycan isolated from Phellinus linteus induces toll-like receptors 2-and 4-mediated maturation of murine dendritic cells via activation of ERK, p38, and NF-κB [J].

Kim, GY ;

Han, MG ;

Song, YS ;

Shin, BC ;

Shin, YI ;

Lee, HJ ;

Moon, DO ;

Lee, CM ;

Kwak, JY ;

Bae, YS ;

Lee, JD ;

Park, YM .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2004, 27 (10) :1656-1662

[17] Acidic polysaccharide isolated from Phellinus linteus induces nitric oxide-mediated tumoricidal activity of macrophages through protein tyrosine kinase and protein kinase C [J].

Kim, GY ;

Oh, YH ;

Park, YM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 309 (02) :399-407

[18] Proteoglycan isolated from Phellinus linteus activates murine B lymphocytes via protein kinase C and protein tyrosine kinase [J].

Kim, GY ;

Park, SK ;

Lee, MK ;

Lee, SH ;

Oh, YH ;

Kwak, JY ;

Yoon, S ;

Lee, JD ;

Park, YM .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2003, 3 (09) :1281-1292

[19] Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus [J].

Kim, HM ;

Han, SB ;

Oh, GT ;

Kim, YH ;

Hong, DH ;

Hong, ND ;

Yoo, ID .

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1996, 18 (05) :295-303

[20] Protein-bound polysaccharide from Phellinus linteus induces G2/M phase arrest and apoptosis in SW480 human colon cancer cells [J].

Li, G ;

Kim, DH ;

Kim, TD ;

Park, BJ ;

Park, HD ;

Park, JI ;

Na, MK ;

Kim, HC ;

Hong, ND ;

Lim, K ;

Hwang, BD ;

Yoon, WH .

CANCER LETTERS, 2004, 216 (02) :175-181

← 1 2 3 →