(p)ppGpp: Still Magical?

被引：892

作者：

Potrykus, Katarzyna ^{[1
]}

Cashel, Michael ^{[1
]}

机构：

[1] NICHHD, NIH, Mol Genet Lab, Bethesda, MD 20892 USA

来源：

ANNUAL REVIEW OF MICROBIOLOGY | 2008年 / 62卷

关键词：

stringent response; transcription; stress; pathogenesis; Rel/Spo; homologs;

D O I：

10.1146/annurev.micro.62.081307.162903

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The fundamental details of how nutritional stress leads to elevating (p)ppGpp are questionable. By common usage, the meaning of the stringent response has evolved from the specific response to (p)ppGpp provoked by amino acid starvation to all responses caused by elevating (p)ppGpp by any means. Different responses have similar as well as dissimilar positive and negative effects on gene expression and metabolism. The different ways that different bacteria seem to exploit their capacities to form and respond to (p)ppGpp are already impressive despite an early stage of discovery. Apparently, (p)ppGpp can contribute to regulation of many aspects of microbial cell biology that are sensitive to changing nutrient availability: growth, adaptation, secondary metabolism, survival, persistence, cell division, motility, biofilms, development, competence, and virulence. Many basic questions still exist. This review tries to focus on some issues that linger even for the most widely characterized bacterial strains.

引用

页码：35 / 51

页数：17

共 85 条

[11] ppGpp regulation of RpoS degradation via anti-adaptor protein IraP
Bougdour, Alexandre
Gottesman, Susan
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (31) : 12896 - 12901
[12] New horizons for (p)ppGpp in bacterial and plant physiology
Braeken, K
Moris, M
Daniels, R
Vanderleyden, J
Michiels, J
[J]. TRENDS IN MICROBIOLOGY, 2006, 14 (01) : 45 - 54
[13] Bremer H., 1996, ESCHERICHIA COLI SAL, V2nd, P1553
[14] DksA affects ppGpp induction of RpoS at a translational level
Brown, L
Gentry, D
Elliott, T
Cashel, M
[J]. JOURNAL OF BACTERIOLOGY, 2002, 184 (16) : 4455 - 4465
[15] Structural and biochemical analysis of the Obg GTP binding protein
Buglino, J
Shen, V
Hakimian, P
Lima, CD
[J]. STRUCTURE, 2002, 10 (11) : 1581 - 1592
[16] Cashel M, 1996, ESCHERICHIA COLI SAL, P1458
[17] The mediator for stringent control, ppGpp, binds to the β-subunit of Escherichia coli RNA polymerase
Chatterji, D
Fujita, N
Ishihama, A
[J]. GENES TO CELLS, 1998, 3 (05) : 279 - 287
[18] The study of guanosine 5′-diphosphate 3′-diphosphate-mediated transcription regulation in vitro using a coupled transcription-translation system
Choy, HE
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (10) : 6783 - 6789
[19] Induction of competence regulons as a general response to stress in gram-positive bacteria
Claverys, Jean-Pierre
Prudhomme, Marc
Martin, Bernard
[J]. ANNUAL REVIEW OF MICROBIOLOGY, 2006, 60 : 451 - 475
[20] ppGpp and DksA likely regulate the activity of the extracytoplasmic stress factor σE in Escherichia coli by both direct and indirect mechanisms
Costanzo, Alessandra
Nicoloff, Herve
Barchinger, Sarah E.
Banta, Amy B.
Gourse, Richard L.
Ades, Sarah E.
[J]. MOLECULAR MICROBIOLOGY, 2008, 67 (03) : 619 - 632

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