Metal coordination-directed hydroxylation of steroids with a novel artificial P-450 catalyst

被引：56

作者：

Fang, ZL ^{[1
]}

Breslow, R ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 02期

关键词：

D O I：

10.1021/ol052589i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel catalyst has been synthesized in which a manganese-porphyrin unit is linked to two 2,2 '-bipyridyl groups and two pentafluorophenyl groups in trans fashion on its four meso positions. Relative to a previous catalyst in which the manganese-porphyrin had four 2,2 '-bipyridyl groups, the new catalyst, in the presence of Cu2+ ions as coordinating linkers, catalyzes the oxidation of a steroid substrate with much better regioselectivity and higher turnover numbers.

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页码：251 / 254

页数：4

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