Colloidal Ordered Assemblies in a Polymer Shell-A Novel Type of Magnetic Nanobeads for Theranostic Applications

被引:51
作者
Bigall, Nadja C. [1 ]
Wilhelm, Claire [2 ]
Beoutis, Marie-Lys [2 ]
Garcia-Hernandez, Mar [3 ]
Khan, Abid A. [4 ]
Giannini, Cinzia [6 ]
Sanchez-Ferrer, Antoni [7 ]
Mezzenga, Raffaele [7 ]
Materia, Maria Elena [1 ]
Garcia, Miguel A. [8 ,9 ]
Gazeau, Florence [2 ]
Bittner, Alexander M. [4 ,5 ]
Manna, Liberato [1 ]
Pellegrino, Teresa [1 ,10 ]
机构
[1] Ist Italiano Tecnol, I-16163 Genoa, Italy
[2] Univ Paris Diderot, CNRS, UMR7057, Lab MSC, F-75205 Paris 13, France
[3] CSIC, Inst Ciencia Mat Madrid, E-28049 Madrid, Spain
[4] CIC NanoGUNE Consolider Donostia, E-20018 San Sebastian, Spain
[5] Ikerbasque, Bilbao 48011, Spain
[6] CNR, Ist Cristallog, I-70126 Bari, Italy
[7] ETH, Inst Food Nutr & Hlth, CH-8092 Zurich, Switzerland
[8] CSIC, Inst Ceram & Consejo Vidrio, E-28049 Madrid, Spain
[9] IMDEA Nanociencia, E-28049 Madrid, Spain
[10] CNR, NNL, Nanosci Inst, I-73100 Lecce, Italy
基金
欧洲研究理事会;
关键词
colloidal assemblies; polymer shell; MRI contrast agents; magnetic nanoparticles; CUBIC LATTICE SYSTEMS; INTERPARTICLE INTERACTIONS; HYDROPHOBIC NANOCRYSTALS; ELASTIC-SCATTERING; NANOPARTICLES; FLUORESCENT; RELAXIVITY; PARTICLES; AGENTS; SIZE;
D O I
10.1021/cm3036746
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
We present the synthesis of polymer embedded colloidal ordered assemblies, built from highly ordered superparamagnetic manganese iron oxide nanocrystals. Each assembly is wrapped into a thin polymer shell. In-depth characterization of the nanoparticles by TEM, SAXS, SQUID, and magnetophoresis indicates that these colloidal hybrids exhibit high mobilities in external magnetic fields, and that they could efficiently serve as contrast enhancers in magnetic resonance imaging.
引用
收藏
页码:1055 / 1062
页数:8
相关论文
共 34 条
[11]   N-Alkyl-PEI-Functionalized Iron Oxide Nanoclusters for Efficient siRNA Delivery [J].
Liu, Gang ;
Xie, Jin ;
Zhang, Fan ;
Wang, Zhiyong ;
Luo, Kui ;
Zhu, Lei ;
Quan, Qimeng ;
Niu, Gang ;
Lee, Seulki ;
Ai, Hua ;
Chen, Xiaoyuan .
SMALL, 2011, 7 (19) :2742-2749
[12]   Novel synthesis of superparamagnetic magnetite nanoclusters for biomedical applications [J].
Maity, Dipak ;
Chandrasekharan, Prashant ;
Pradhan, Pallab ;
Chuang, Kai-Hsiang ;
Xue, Jun-Min ;
Feng, Si-Shen ;
Ding, Jun .
JOURNAL OF MATERIALS CHEMISTRY, 2011, 21 (38) :14717-14724
[13]   Generation of superparamagnetic liposomes revealed as highly efficient MRI contrast agents for in vivo imaging [J].
Martina, MS ;
Fortin, JP ;
Ménager, C ;
Clément, O ;
Barratt, G ;
Grabielle-Madelmont, C ;
Gazeau, F ;
Cabuil, V ;
Lesieur, S .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (30) :10676-10685
[14]   ELASTIC-SCATTERING FROM CUBIC LATTICE SYSTEMS WITH PARACRYSTALLINE DISTORTION .2. [J].
MATSUOKA, H ;
TANAKA, H ;
IIZUKA, N ;
HASHIMOTO, T ;
ISE, N .
PHYSICAL REVIEW B, 1990, 41 (06) :3854-3856
[15]   ELASTIC-SCATTERING FROM CUBIC LATTICE SYSTEMS WITH PARACRYSTALLINE DISTORTION [J].
MATSUOKA, H ;
TANAKA, H ;
HASHIMOTO, T ;
ISE, N .
PHYSICAL REVIEW B, 1987, 36 (03) :1754-1765
[16]   Mechanism of Magnetic Relaxation Switching Sensing [J].
Min, Changwook ;
Shao, Huilin ;
Liong, Monty ;
Yoon, Tae-Jong ;
Weissleder, Ralph ;
Lee, Hakho .
ACS NANO, 2012, 6 (08) :6821-6828
[17]   Hydrophobic nanocrystals coated with an amphiphilic polymer shell: A general route to water soluble nanocrystals [J].
Pellegrino, T ;
Manna, L ;
Kudera, S ;
Liedl, T ;
Koktysh, D ;
Rogach, AL ;
Keller, S ;
Radler, J ;
Natile, G ;
Parak, WJ .
NANO LETTERS, 2004, 4 (04) :703-707
[18]   Nanosized particles made in colloidal assemblies [J].
Pileni, MP .
LANGMUIR, 1997, 13 (13) :3266-3276
[19]   DIE RONTGENKLEINWINKELSTREUUNG VON DICHTGEPACKTEN KOLLOIDEN SYSTEMEN .1. [J].
POROD, G .
KOLLOID-ZEITSCHRIFT AND ZEITSCHRIFT FUR POLYMERE, 1951, 124 (02) :83-114
[20]   "Nanohybrids" Based on pH-Responsive Hydrogels and Inorganic Nanoparticles for Drug Delivery and Sensor Applications [J].
Riedinger, Andreas ;
Leal, Manuel Pernia ;
Deka, Smriti R. ;
George, Chandramohan ;
Franchini, Isabella R. ;
Falqui, Andrea ;
Cingolani, Roberto ;
Pellegrino, Teresa .
NANO LETTERS, 2011, 11 (08) :3136-3141