A simple, stereoselective synthesis of ketomethylene dipeptide isosteres

被引：27

作者：

Hoffman, RV

Tao, JH

机构：

[1] Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces

来源：

TETRAHEDRON | 1997年 / 53卷 / 21期

关键词：

D O I：

10.1016/S0040-4020(97)00410-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An exceedingly simple, general, and stereoselective method for the preparation of ketomethylene dipeptide isosteres (5-(carbobenzyloxyamino)-2-alkyl-gamma-ketoesters) from Cbz-protected amino acids and scalemic 2-triflyloxy esters has been developed. The method is short (three steps), efficient, and highly diastereoselective and enantioselective. (C) 1997 Elsevier Science Ltd.

引用

页码：7119 / 7126

页数：8

共 23 条

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