In Leishmaniasis Due to Leishmania guyanensis Infection, Distinct Intralesional Interleukin-10 and Foxp3 mRNA Expression Are Associated with Unresponsiveness to Treatment

被引：34

作者：

Bourreau, Eliane ^{[3
]}

Ronet, Catherine ^{[1
]}

Darsissac, Edith ^{[3
]}

Lise, Marie-Claire ^{[3
]}

Sainte Marie, Dominique ^{[2
]}

Clity, Emmanuel ^{[2
]}

Tacchini-Cottier, Fabienne ^{[1
]}

Couppie, Pierre ^{[2
]}

Launois, Pascal ^{[1
,3
]}

机构：

[1] Univ Lausanne, Dept Biochem, WHO IRTC, CH-1066 Epalinges, Switzerland

[2] Ctr Hosp Andree Rosemon, Inst Guyanais Dermatol Trop, EA 2188, Cayenne, French Guiana

[3] Inst Pasteur, Cayenne, French Guiana

来源：

JOURNAL OF INFECTIOUS DISEASES | 2009年 / 199卷 / 04期

关键词：

EXPERIMENTAL VISCERAL LEISHMANIASIS; LOCALIZED CUTANEOUS LEISHMANIASIS; REGULATORY T-CELLS; GAMMA-INTERFERON; AMPHOTERICIN-B; CHEMOTHERAPY; IL-10; HOST;

D O I：

10.1086/596508

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The presence of intralesional natural regulatory T cells, characterized by the expression of Foxp3 mRNA, was analyzed in patients with localized leishmaniasis due to Leishmania guyanensis infection that was unresponsive to treatment with pentamidine isethionate. Foxp3 mRNA levels were associated with unresponsiveness to treatment among patients with a lesion duration of >= 1 month, but this association was not observed among patients with a lesion duration of < 1 month. In conclusion, high intralesional expression of Foxp3 might be an indicator of poor response to treatment, depending on the duration of lesions.

引用

页码：576 / 579

页数：4

共 15 条

[1]

CD4+CD25-Foxp3- Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis [J].

Anderson, Charles F. ;

Oukka, Mohammed ;

Kuchroo, Vijay J. ;

Sacks, David .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (02) :285-297

[2]

Th2 responses predominate during the early phases of infection in patients with localized cutaneous leishmaniasis and precede the development of Th1 responses [J].

Bourreau, E ;

Gardon, J ;

Pradinaud, R ;

Pascalis, H ;

Prévot-Linguet, G ;

Kariminia, A ;

Pascal, L .

INFECTION AND IMMUNITY, 2003, 71 (04) :2244-2246

[3]

High intralesional interleukin-10 messenger RNA expression in localized cutaneous Leishmaniasis is associated with unresponsiveness to treatment [J].

Bourreau, E ;

Prévot, G ;

Gardon, J ;

Pradinaud, R ;

Launois, P .

JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (12) :1628-1630

[4]

CD4+ CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells [J].

Campanelli, AP ;

Roselino, AM ;

Cavassani, KA ;

Pereira, MSF ;

Mortara, RA ;

Brodskyn, CI ;

Gonçalves, HS ;

Belkaid, Y ;

Barral-Netto, M ;

Barral, A ;

Silva, JS .

JOURNAL OF INFECTIOUS DISEASES, 2006, 193 (09) :1313-1322

[5]

Drug resistance in leishmaniasis [J].

Croft, SL ;

Sundar, S ;

Fairlamb, AH .

CLINICAL MICROBIOLOGY REVIEWS, 2006, 19 (01) :111-+

[6]

Control of regulatory T cell development by the transcription factor Foxp3 [J].

Hori, S ;

Nomura, T ;

Sakaguchi, S .

SCIENCE, 2003, 299 (5609) :1057-1061

[7]

Treatment of visceral leishmaniasis in HIV-infected patients:: a randomized trial comparing meglumine antimoniate with amphotericin B [J].

Laguna, F ;

López-Vélez, R ;

Pulido, F ;

Salas, A ;

Torre-Cisneros, J ;

Torres, E ;

Medrano, FJ ;

Sanz, J ;

Picó, G ;

Gómez-Rodrigo, J ;

Pasquau, J ;

Alvar, J .

AIDS, 1999, 13 (09) :1063-1069

[8]

REQUIREMENT FOR T-CELLS AND EFFECT OF LYMPHOKINES IN SUCCESSFUL CHEMOTHERAPY FOR AN INTRACELLULAR INFECTION - EXPERIMENTAL VISCERAL LEISHMANIASIS [J].

MURRAY, HW ;

OCA, MJ ;

GRANGER, AM ;

SCHREIBER, RD .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (04) :1253-1257

[9]

Roles of endogenous gamma interferon and macrophage microbicidal mechanisms in host response to chemotherapy in experimental visceral leishmaniasis [J].

Murray, HW ;

Delph-Etienne, S .

INFECTION AND IMMUNITY, 2000, 68 (01) :288-293

[10]

TREATMENT OF EXPERIMENTAL VISCERAL LEISHMANIASIS IN A T-CELL-DEFICIENT HOST - RESPONSE TO AMPHOTERICIN-B AND PENTAMIDINE [J].

MURRAY, HW ;

HARIPRASHAD, J ;

FICHTL, RE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (07) :1504-1505

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