PhI(OAc)2-Mediated Synthesis of 6-(Trifluoromethyl)phenanthridines by Oxidative Cyclization of 2-Isocyanobiphenyls with CF3SiMe3 under Metal-Free Conditions

被引：182

作者：

Wang, Qile ^{[1
]}

Dong, Xichang ^{[1
]}

Xiao, Tiebo ^{[1
]}

Zhou, Lei ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 18期

基金：

中国国家自然科学基金;

关键词：

C-H TRIFLUOROMETHYLATION; SILVER-MEDIATED TRIFLUOROMETHYLATION; ARYL BORONIC ACIDS; CATALYZED TRIFLUOROMETHYLATION; PHENANTHRIDINE DERIVATIVES; HETEROAROMATIC-COMPOUNDS; AROMATIC-COMPOUNDS; BOND FORMATION; COPPER; FLUORINE;

D O I：

10.1021/ol4022589

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient method for the synthesis of 6-(trifluoromethyl)phenanthridines through oxidative cyclization of 2-isocyanobiphenyls with CF3SiMe3 under metal-free conditions was developed. The reaction allows the direct formation of C-CF3 bonds and rapid access to phenanthridine ring systems in one catalytic cycle.

引用

页码：4846 / 4849

页数：4

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