Enantioselective lipase-catalyzed reactions of methyl pipecolinate:: transesterification and N-acylation

被引：43

作者：

Liljeblad, A

Lindborg, J

Kanerva, A

Katajisto, J

Kanerva, LT

机构：

[1] Univ Turku, Lab Synthet Drug Chem, FIN-20520 Turku, Finland

[2] Univ Turku, Dept Chem, FIN-20520 Turku, Finland

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 13期

关键词：

Candida antarctica lipase A; Candida antarctica lipase B; pipecolic acid; methyl pipecolinate; resolution;

D O I：

10.1016/S0040-4039(02)00288-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The present research introduces the highly (S)-selective (Emuch greater than100) acylation at the secondary ring nitrogen of methyl pipecolinate as a novel resolution method with Candida antarctica lipase A. Catalysis by lipase B leads to reactions at the methyl ester function of the substrate in an almost non-enantioselective manner. (C) 2002 Elsevier Science Ltd. All rights reserved.

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收藏

页码：2471 / 2474

页数：4

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