Electrospray ionization source geometry for mass spectrometry: past, present, and future

被引:101
作者
Manisali, I
Chen, DDY
Schneider, BB
机构
[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada
[2] MDS SCIEX, Concord, ON L4K 4V8, Canada
关键词
atmospheric pressure ionization; commercial ion source design; electrospray ionization; ion source; ion source geometry; mass spectrometry;
D O I
10.1016/j.trac.2005.07.007
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The geometry of an electrospray ion source plays important roles in the processes of analyte desolvation, ionization, transportation, and detection in a mass spectrometer. We provide a brief account of the scientific principles involved in developing an electrospray ion source, and in the various geometries used to improve the sensitivity of mass spectrometry. We also present some popular configurations currently available and outline future trends in this research area. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:243 / 256
页数:14
相关论文
共 139 条
[21]  
Bruins A. P., 1997, ELECTROSPRAY IONIZAT, P107
[22]   ION SPRAY INTERFACE FOR COMBINED LIQUID CHROMATOGRAPHY/ATMOSPHERIC PRESSURE IONIZATION MASS-SPECTROMETRY [J].
BRUINS, AP ;
COVEY, TR ;
HENION, JD .
ANALYTICAL CHEMISTRY, 1987, 59 (22) :2642-2646
[23]   CAPILLARY ELECTROPHORESIS MASS-SPECTROMETRY [J].
CAI, JY ;
HENION, J .
JOURNAL OF CHROMATOGRAPHY A, 1995, 703 (1-2) :667-692
[24]   Practical implications of some recent studies in electrospray ionization fundamentals [J].
Cech, NB ;
Enke, CG .
MASS SPECTROMETRY REVIEWS, 2001, 20 (06) :362-387
[25]   Sheathless capillary electrophoresis/electrospray mass spectrometry using a carbon-coated tapered fused-silica capillary with a beveled edge [J].
Chang, YZ ;
Chen, YR ;
Her, GR .
ANALYTICAL CHEMISTRY, 2001, 73 (21) :5083-5087
[26]   AN ELECTROSPRAY-IONIZATION MASS-SPECTROMETER WITH NEW FEATURES [J].
CHOWDHURY, SK ;
KATTA, V ;
CHAIT, BT .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1990, 4 (03) :81-87
[27]  
Cole R.B., 1997, Electrospray Ionization Mass Spectrometry
[28]  
Cole RB, 2000, J MASS SPECTROM, V35, P763, DOI 10.1002/1096-9888(200007)35:7<763::AID-JMS16>3.3.CO
[29]  
2-R
[30]  
CORMIA PH, 2004, P 52 ASMS C MASS SPE