Five labdane diterpenoids from the seeds of Aframomum zambesiacum

被引：41

作者：

Kenmogne, M

Prost, E

Harakat, D

Jacquier, MJ

Frédérich, M

Sondengam, LB

Zèches, M

Waffo-Téguo, P

机构：

[1] Univ Reims, IFR Biomol 53, Lab Pharmacognosie, CNRS,FRE 2715, F-51687 Reims 02, France

[2] Univ Dschang, Fac Sci, Dept Chem, Dschang, Cameroon

[3] Univ Liege, Nat & Snthet Drugs Res Ctr, Lab Pharmacognosy, B-4000 Liege, Belgium

[4] Univ Reims, Fac Sci, CNRS, UMR 6519,Lab React Select & Applicat, F-51687 Reims 2, France

[5] Univ Yaounde, Fac Sci, Dept Organ Chem, Yaounde, Cameroon

来源：

PHYTOCHEMISTRY | 2006年 / 67卷 / 05期

基金：

以色列科学基金会;

关键词：

Aframomum zambesiacum; Zingiberaceae; labdane diterpenoids; antiplasmodial activity; Plasmodium falciparum;

D O I：

10.1016/j.phytochem.2005.10.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five labdane diterpenoids, (3-5), zambesiacolactone A (7) and zambesiacolactone B (8), were isolated from the seeds of Aframomum zambesiacum (Baker) K. Schum., along with five known labdanes and a linear sesquiterpene, nerolidol. Their structures were elucidated by spectroscopic analysis. Their antiplasmodial activity was evaluated in vitro against Plasmodium falciparum. Compound 3 was the most active with an IC50 value of 4.97 mu M. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：433 / 438

页数：6

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