Integrative analysis of metabolic networks: from peaks to flux models?

被引:9
作者
Lange, B. Markus
机构
[1] Washington State Univ, Inst Biol Chem, Pullman, WA 99164 USA
[2] Washington State Univ, Ctr Integrated Biotechnol, Pullman, WA 99164 USA
基金
美国国家科学基金会;
关键词
D O I
10.1016/j.pbi.2006.03.003
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Recent developments in genomic and post-genomic technologies have led to the amassment of data describing genome sequences, transcript, protein and metabolite abundances, protein modifications, and protein-protein and protein-DNA interactions. Such technologies have vastly expanded the inventory of detectable molecular species and can be used to describe their interdependence, but they have yet to fulfill their promise in enhancing our knowledge of how flux through metabolic pathways is regulated. A convergence of traditional reductionistic and novel holistic experimental approaches could aid in elucidating flux control.
引用
收藏
页码:220 / 226
页数:7
相关论文
共 74 条
  • [1] Genomics-based selection and functional characterization of triterpene glycosyltransferases from the model legume Medicago truncatula
    Achnine, L
    Huhman, DV
    Farag, MA
    Sumner, LW
    Blount, JW
    Dixon, RA
    [J]. PLANT JOURNAL, 2005, 41 (06) : 875 - 887
  • [2] Mass spectrometry-based proteomics
    Aebersold, R
    Mann, M
    [J]. NATURE, 2003, 422 (6928) : 198 - 207
  • [3] Biosynthesis of cellulose-enriched tension wood in Populus:: global analysis of transcripts and metabolites identifies biochemical and developmental regulators in secondary wall biosynthesis
    Andersson-Gunnerås, S
    Mellerowicz, EJ
    Love, J
    Segerman, B
    Ohmiya, Y
    Coutinho, PM
    Nilsson, P
    Henrissat, B
    Moritz, T
    Sundberg, B
    [J]. PLANT JOURNAL, 2006, 45 (02) : 144 - 165
  • [4] Gene Ontology: tool for the unification of biology
    Ashburner, M
    Ball, CA
    Blake, JA
    Botstein, D
    Butler, H
    Cherry, JM
    Davis, AP
    Dolinski, K
    Dwight, SS
    Eppig, JT
    Harris, MA
    Hill, DP
    Issel-Tarver, L
    Kasarskis, A
    Lewis, S
    Matese, JC
    Richardson, JE
    Ringwald, M
    Rubin, GM
    Sherlock, G
    [J]. NATURE GENETICS, 2000, 25 (01) : 25 - 29
  • [5] A dynamic whole-plant model of integrated metabolism of nitrogen and carbon. 2. Balanced growth driven by C fluxes and regulated by signals from C and N substrate
    Bijlsma, RJ
    Lambers, H
    [J]. PLANT AND SOIL, 2000, 220 (1-2) : 71 - 87
  • [6] Potential of metabolomics as a functional genomics tool
    Bino, RJ
    Hall, RD
    Fiehn, O
    Kopka, J
    Saito, K
    Draper, J
    Nikolau, BJ
    Mendes, P
    Roessner-Tunali, U
    Beale, MH
    Trethewey, RN
    Lange, BM
    Wurtele, ES
    Sumner, LW
    [J]. TRENDS IN PLANT SCIENCE, 2004, 9 (09) : 418 - 425
  • [7] Minimum information about a microarray experiment (MIAME) - toward standards for microarray data
    Brazma, A
    Hingamp, P
    Quackenbush, J
    Sherlock, G
    Spellman, P
    Stoeckert, C
    Aach, J
    Ansorge, W
    Ball, CA
    Causton, HC
    Gaasterland, T
    Glenisson, P
    Holstege, FCP
    Kim, IF
    Markowitz, V
    Matese, JC
    Parkinson, H
    Robinson, A
    Sarkans, U
    Schulze-Kremer, S
    Stewart, J
    Taylor, R
    Vilo, J
    Vingron, M
    [J]. NATURE GENETICS, 2001, 29 (04) : 365 - 371
  • [8] Gene expression and metabolite profiling of Populus euphratica growing in the Negev desert -: art. no. R101
    Brosché, M
    Vinocur, B
    Alatalo, ER
    Lamminmäki, A
    Teichmann, T
    Ottow, EA
    Djilianov, D
    Afif, D
    Bogeat-Triboulot, MB
    Altman, A
    Polle, A
    Dreyer, E
    Rudd, S
    Lars, P
    Auvinen, P
    Kangasjärvi, J
    [J]. GENOME BIOLOGY, 2005, 6 (12)
  • [9] Evolution in action: Following function in duplicated floral homeotic genes
    Causier, B
    Castillo, R
    Zhou, JL
    Ingram, R
    Xue, YB
    Schwarz-Sommer, Z
    Davies, B
    [J]. CURRENT BIOLOGY, 2005, 15 (16) : 1508 - 1512
  • [10] A prominent role for the CBF cold response pathway in configuring the low-temperature metabolome of Arabidopsis
    Cook, D
    Fowler, S
    Fiehn, O
    Thomashow, MF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (42) : 15243 - 15248