The Biology/Disease-driven Human Proteome Project (B/D-HPP): Enabling Protein Research for the Life Sciences Community

被引：82

作者：

Aebersold, Ruedi ^{[1
,2
]}

Bader, Gary D. ^{[3
]}

Edwards, Aled M. ^{[4
,5
]}

van Eyk, Jennifer E. ^{[6
]}

Kussmann, Martin ^{[7
,8
,9
]}

Qin, Jun ^{[10
,11
]}

Omenn, Gilbert S. ^{[12
,13
,14
,15
,16
]}

机构：

[1] Swiss Fed Inst Technol, Inst Mol Syst Biol, Dept Biol, Zurich, Switzerland

[2] Univ Zurich, Fac Sci, Zurich, Switzerland

[3] Univ Toronto, Fac Med, Donnelly Ctr, Toronto, ON, Canada

[4] Univ Toronto, Toronto, ON M5S 1A8, Canada

[5] Ontario Canc Inst, Div Canc Genom & Prote, Toronto, ON M5G 2M9, Canada

[6] Johns Hopkins Univ, Sch Med, Dept Med, Johns Hopkins Bayview Prote Ctr,Div Cardiol, Baltimore, MD 21205 USA

[7] Nestle Inst Hlth Sci, Prote & Metabon Core, Lausanne, Switzerland

[8] Ecole Polytech Fed Lausanne, Fac Life Sci, Lausanne, Switzerland

[9] Aarhus Univ, Fac Sci, Aarhus, Denmark

[10] Beijing Proteome Res Ctr, Beijing Inst Radiat Med, State Key Lab Prote, Beijing, Peoples R China

[11] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[12] Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

[13] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[14] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA

[15] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA

[16] Inst Syst Biol, Seattle, WA 98101 USA

来源：

JOURNAL OF PROTEOME RESEARCH | 2013年 / 12卷 / 01期

关键词：

Human proteome project; proteomics; mass spectrometry; affinity reagents; network biology; human disease; biological processes; VALIDATION;

D O I：

10.1021/pr301151m

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The biology and disease oriented branch of the Human Proteome Project (B/D-HPP) was established by the Human Proteome Organization (HUPO) with the main goal of supporting the broad application of state-of-the-art measurements of proteins and proteomes by life scientists studying the molecular mechanisms of biological processes and human disease. This will be accomplished through the generation of research and informational resources that will support the routine and definitive measurement of the process or disease relevant proteins. The B/D-HPP is highly complementary to the C-HPP and will provide datasets and biological characterization useful to the C-HPP teams. In this manuscript we describe the goals, the plans, and the current status of the of the B/D-HPP.

引用

页码：23 / 27

页数：5

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