Mediterranean diet and colorectal cancer risk: results from a European cohort

被引：154

作者：

Bamia, Christina ^{[1
]}

Lagiou, Pagona ^{[1
,2
,3
]}

Buckland, Genevieve ^{[4
]}

Grioni, Sara ^{[5
]}

Agnoli, Claudia ^{[6
]}

Taylor, Aliki J. ^{[7
]}

Dahm, Christina C. ^{[8
]}

Overvad, Kim ^{[8
]}

Olsen, Anja ^{[9
]}

Tjonneland, Anne ^{[9
]}

Cottet, Vanessa ^{[10
,11
]}

Boutron-Ruault, Marie-Christine ^{[10
,11
]}

Morois, Sophie ^{[10
,11
]}

Grote, Verena ^{[12
]}

Teucher, Birgit ^{[12
]}

Boeing, Heiner ^{[13
]}

Buijsse, Brian ^{[13
]}

Trichopoulos, Dimitrios ^{[2
,3
,14
]}

Adarakis, George ^{[14
]}

Tumino, Rosario ^{[15
]}

Naccarati, Alessio ^{[16
]}

Panico, Salvatore ^{[17
]}

Palli, Domenico ^{[18
]}

Bueno-de-Mesquita, H. Bas ^{[19
,20
]}

van Duijnhoven, Fraenzel J. B. ^{[19
,21
]}

Peeters, Petra H. M. ^{[22
,23
]}

Engeset, Dagrun ^{[24
]}

Skeie, Guri ^{[24
]}

Lund, Eiliv ^{[24
]}

Sanchez, Maria-Jose ^{[25
,26
]}

Barricarte, Aurelio ^{[26
,27
,28
]}

Huerta, Jose-Maria ^{[26
,29
]}

Ramon Quiros, J. ^{[30
]}

Dorronsoro, Miren ^{[26
,31
]}

Ljuslinder, Ingrid ^{[32
]}

Palmqvist, Richard ^{[33
]}

Drake, Isabel ^{[34
]}

Key, Timothy J. ^{[35
]}

Khaw, Kay-Tee ^{[36
]}

Wareham, Nick ^{[37
]}

Romieu, Isabelle ^{[38
]}

Fedirko, Veronika ^{[38
]}

Jenab, Mazda ^{[38
]}

Romaguera, Dora ^{[23
]}

Norat, Teresa ^{[23
]}

Trichopoulou, Antonia ^{[1
,3
,14
]}

机构：

[1] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[3] Acad Athens, Bur Epidemiol Res, Athens, Greece

[4] Catalan Inst Oncol ICO, Unit Nutr Environm & Canc, Canc Epidemiol Res Programme, Barcelona, Spain

[5] IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy

[6] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[7] Univ Birmingham, Dept Publ Hlth Epidemiol & Biostat, Birmingham, W Midlands, England

[8] Aarhus Univ, Epidemiol Sect, Dept Publ Hlth, Aarhus, Denmark

[9] Danish Canc Soc Res Ctr, Copenhagen, Denmark

[10] Inst Gustave Roussy, Ctr Res Epidemiol & Populat Hlth, INSERM, U1018, F-94805 Villejuif, France

[11] Paris South Univ, UMRS 1018, F-94805 Villejuif, France

[12] German Canc Res Ctr, Heidelberg, Germany

[13] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Potsdam, Germany

[14] Hellen Hlth Fdn, Athens, Greece

[15] Civile MP Arezzo Hosp, Canc Registry Histopathol Unit, ASP, Ragusa, Italy

[16] Human Genet Fdn HuGeF, Turin, Italy

[17] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[18] ISPO, Canc Res & Prevent Inst, Mol & Nutrit Epidemiol Unit, Florence, Italy

[19] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[20] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[21] Wageningen Univ, Div Human Nutr, NL-6700 AP Wageningen, Netherlands

[22] Univ Med Ctr Utrecht, Julius Ctr, Utrecht, Netherlands

[23] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Fac Med, Dept Epidemiol & Biostat, London, England

[24] Univ Tromso, Dept Community Med, Tromso, Norway

[25] Andalusian Sch Publ Hlth, Granada, Spain

[26] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[27] Navarre Publ Hlth Inst, Pamplona, Spain

[28] Navarre Publ Univ, Navarra, Spain

[29] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[30] Publ Hlth Directorate, Asturias, Spain

[31] BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, Dept Hlth, San Sebastian, Spain

[32] Umea Univ, Dept Radiat Sci, Umea, Sweden

[33] Umea Univ, Dept Med Biosci, Umea, Sweden

[34] Lund Univ, Nutr Epidemiol Res Grp, Dept Clin Sci, Malmo, Sweden

[35] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[36] Univ Cambridge, Cambridge, England

[37] MRC, Epidemiol Unit, Cambridge, England

[38] Int Agcy Res Canc IARC WHO, Lyon, France

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2013年 / 28卷 / 04期

基金：

英国医学研究理事会;

关键词：

Mediterranean diet; Colorectal cancer; Cohort study; PHYSICAL-ACTIVITY; RECTAL CANCERS; EPIC COHORT; NUTRITION; ADHERENCE; PATTERNS; SURVIVAL; HEALTH; METAANALYSIS; POPULATION;

D O I：

10.1007/s10654-013-9795-x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

The authors investigated the association of adherence to Mediterranean diet with colorectal cancer (CRC) risk in the European Prospective Investigation into Cancer and nutrition study. Adherence to Mediterranean diet was expressed through two 10-unit scales, the Modified Mediterranean diet score (MMDS) and the Centre-Specific MMDS (CSMMDS). Both scales share the same dietary components but differ in the cut-off values that were used for these components in the construction of the scales. Adjusted hazard ratios (HR) for the associations of these scales with CRC incidence were estimated. After 5,296,617 person-years of follow-up, 4,355 incident CRC cases were identified. A decreased risk of CRC, of 8 and 11 % was estimated when comparing the highest (scores 6-9) with the lowest (scores 0-3) adherence to CSMMDS and MMDS respectively. For MMDS the HR was 0.89 (95 % confidence interval (CI): 0.80, 0.99). A 2-unit increment in either Mediterranean scale was associated with a borderline statistically significant 3 to 4 % reduction in CRC risk (HR for MMDS: 0.96; 95 % CI: 0.92, 1.00). These associations were somewhat more evident, among women, were mainly manifested for colon cancer risk and their magnitude was not altered when alcohol was excluded from MMDS. These findings suggest that following a Mediterranean diet may have a modest beneficial effect on CRC risk.

引用

页码：317 / 328

页数：12

共 35 条

[1]

[Anonymous], 2009, STAT STAT SOFTW REL

[2]

[Anonymous], 1980, SCIENCE, DOI DOI 10.1126/SCIENCE.208.4448.1138

[3]

[Anonymous], CONT UPD PROJ INT RE

[4]

Adherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study [J].

Buckland, Genevieve ;

Agudo, Antonio ;

Lujan, Leila ;

Jakszyn, Paula ;

Bueno-de-Mesquita, H. Bas ;

Palli, Domenico ;

Boeing, Heiner ;

Carneiro, Fatima ;

Krogh, Vittorio ;

Sacerdote, Carlotta ;

Tumino, Rosario ;

Panico, Salvatore ;

Nesi, Gabriella ;

Manjer, Jonas ;

Regner, Sara ;

Johansson, Ingegerd ;

Stenling, Roger ;

Sanchez, Maria-Jose ;

Dorronsoro, Miren ;

Barricarte, Aurelio ;

Navarro, Carmen ;

Ramon Quiros, J. ;

Allen, Naomi E. ;

Key, Timothy J. ;

Bingham, Sheila ;

Kaaks, Rudolf ;

Overvad, Kim ;

Jensen, Majken ;

Olsen, Anja ;

Tjonneland, Anne ;

Peeters, Petra H. M. ;

Numans, Mattijs E. ;

Ocke, Marga C. ;

Clavel-Chapelon, Francoise ;

Morois, Sophie ;

Boutron-Ruault, Marie-Christine ;

Trichopoulou, Antonia ;

Lagiou, Pagona ;

Trichopoulos, Dimitrios ;

Lund, Eiliv ;

Couto, Elisabeth ;

Boffeta, Paolo ;

Jenab, Mazda ;

Riboli, Elio ;

Romaguera, Dora ;

Mouw, Traci ;

Gonzalez, Carlos A. .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2010, 91 (02) :381-390

[5]

Mediterranean dietary pattern and cancer risk in the EPIC cohort [J].

Couto, E. ;

Boffetta, P. ;

Lagiou, P. ;

Ferrari, P. ;

Buckland, G. ;

Overvad, K. ;

Dahm, C. C. ;

Tjonneland, A. ;

Olsen, A. ;

Clavel-Chapelon, F. ;

Boutron-Ruault, M-C ;

Cottet, V. ;

Trichopoulos, D. ;

Naska, A. ;

Benetou, V. ;

Kaaks, R. ;

Rohrmann, S. ;

Boeing, H. ;

von Ruesten, A. ;

Panico, S. ;

Pala, V. ;

Vineis, P. ;

Palli, D. ;

Tumino, R. ;

May, A. ;

Peeters, P. H. ;

Bueno-de-Mesquita, H. B. ;

Buchner, F. L. ;

Lund, E. ;

Skeie, G. ;

Engeset, D. ;

Gonzalez, C. A. ;

Navarro, C. ;

Rodriguez, L. ;

Sanchez, M-J ;

Amiano, P. ;

Barricarte, A. ;

Hallmans, G. ;

Johansson, I. ;

Manjer, J. ;

Wirfart, E. ;

Allen, N. E. ;

Crowe, F. ;

Khaw, K-T ;

Wareham, N. ;

Moskal, A. ;

Slimani, N. ;

Jenab, M. ;

Romaguera, D. ;

Mouw, T. .

BRITISH JOURNAL OF CANCER, 2011, 104 (09) :1493-1499

[6]

Adherence to the USDA food guide, DASH eating plan, and Mediterranean dietary pattern reduces risk of colorectal adenoma [J].

Dixon, L. Beth ;

Subar, Amy F. ;

Peters, Ulrike ;

Weissfeld, Joel L. ;

Bresalier, Robert S. ;

Risch, Adam ;

Schatzkin, Arthur ;

Hayes, Richard B. .

JOURNAL OF NUTRITION, 2007, 137 (11) :2443-2450

[7]

The evaluation of the diet/disease relation in the EPIC study: considerations for the calibration and the disease models [J].

Ferrari, Pietro ;

Day, Nicholas E. ;

Boshuizen, Hendriek C. ;

Roddam, Andrew ;

Hoffmann, Kurt ;

Thiebaut, Anne ;

Pera, Guillem ;

Overvad, Kim ;

Lund, Eiliv ;

Trichopoulou, Antonia ;

Tumino, Rosario ;

Gullberg, Bo ;

Norat, Teresa ;

Slimani, Nadia ;

Kaaks, Rudolf ;

Riboli, Elio .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2008, 37 (02) :368-378

[8]

Lifetime and baseline alcohol intake and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC) [J].

Ferrari, Pietro ;

Jenab, Mazda ;

Norat, Teresa ;

Moskal, Aurelie ;

Slimani, Nadia ;

Olsen, Anja ;

Tjonneland, Anne ;

Overvad, Kim ;

Jensen, Majken K. ;

Boutron-Ruault, Marie-Christine ;

Clavel-Chapelon, Francoise ;

Morois, Sophie ;

Rohrmann, Sabine ;

Linseisen, Jakob ;

Boeing, Heiner ;

Bergmann, Manuela ;

Kontopoulou, Dimitra ;

Trichopoulou, Antonia ;

Kassapa, Christina ;

Masala, Giovanna ;

Krogh, Vittorio ;

Vineis, Paolo ;

Panico, Salvatore ;

Tumino, Rosario ;

van Gils, Carla H. ;

Peeters, Petra ;

Bueno-de-Mesquita, H. Bas ;

Ocke, Marga C. ;

Skeie, Guri ;

Lund, Eiliv ;

Agudo, Antonio ;

Ardanaz, Eva ;

Lopez, Dolores C. ;

Sanchez, Maria-Jose ;

Quiros, Jose R. ;

Amiano, Pilar ;

Berglund, Goran ;

Manjer, Jonas ;

Palmqvist, Richard ;

Van Guelpen, Bethany ;

Allen, Naomi ;

Key, Tim ;

Bingham, Sheila ;

Mazuir, Mathieu ;

Boffetta, Paolo ;

Kaaks, Rudolf ;

Riboli, Elio .

INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (09) :2065-2072

[9]

Physical activity and risk of colon and rectal cancers:: The European Prospective Investigation into Cancer and Nutrition [J].

Friedenreich, Christine ;

Norat, Teresa ;

Steindorf, Karen ;

Boutron-Ruault, Marie-Christine ;

Pischon, Tobias ;

Mazuir, Mathieu ;

Clavel-Chapelon, Francoise ;

Linseisen, Jakob ;

Boeing, Heiner ;

Bergman, Manuela ;

Johnsen, Nina Forts ;

Tjonneland, Anne ;

Overvad, Kim ;

Mendez, Michelle ;

Quiros, J. Ramon ;

Martinez, Carmen ;

Dorronsoro, Miren ;

Navarro, Carmen ;

Gurrea, Aurelio Barricarte ;

Bingham, Sheila ;

Khaw, Kay-Tee ;

Allen, Naomi ;

Key, Tim ;

Trichopoujou, Antonia ;

Trichopoulos, Dimitrios ;

Orfanou, Natassa ;

Krogh, Vittorio ;

Palli, Domenico ;

Tumino, Rosario ;

Panico, Salvatore ;

Vineis, Paolo ;

Bueno-de-Mesquita, H. Bas ;

Peeters, Petra H. M. ;

Monninkhof, Evelyn ;

Berglund, Goran ;

Manjer, Jonas ;

Ferrari, Pietro ;

Slimani, Nadia ;

Kaaks, Rudolf ;

Riboli, Elio .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (12) :2398-2407

[10]

The Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets and colorectal cancer [J].

Fung, Teresa T. ;

Hu, Frank B. ;

Wu, Kana ;

Chiuve, Stephanie E. ;

Fuchs, Charles S. ;

Giovannucci, Edward .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2010, 92 (06) :1429-1435

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