Molecular mechanism of the metallothionein gene expression mediated by metal-responsive transcription factor 1

被引:19
作者
Otsuka, F [1 ]
机构
[1] Teikyo Univ, Fac Pharmaceut Sci, Dept Toxicol & Environm Hlth, Sagamiko, Kanagawa 1990195, Japan
关键词
metallothionein; metal-responsive element; MTF-1; heavy metal; transcription;
D O I
10.1248/jhs.47.513
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Metal-responsive transcription factor 1 (MTF-1) is essential for activating transcription of the metallothionein genes in response to multiple species of heavy metals by binding to the metal-responsive element (MRE) located in the upstream region of the genes. In contrast, MTF-1 binding to the MRE in vitro is induced only by zinc ions, suggesting that MTF-1 acts as a zinc sensor protein. Although the mechanism allowing such a zinc-responsive factor to respond to various metal species in vivo remains ambiguous, recent information regarding the metal response of MTF-1 and the genes expressed downstream of MTF-1 provides important clues to unraveling the intrinsic mechanism and the biological significance of the MTF-1 functions in vivo.
引用
收藏
页码:513 / 519
页数:7
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