Multiresidue determination of (fluoro)quinolone antibiotics in swine kidney using liquid chromatography-tandem mass spectrometry

被引:82
作者
van Vyncht, G
Jànosi, A
Bordin, G [1 ]
Toussaint, B
Maghuin-Rogister, G
De Pauw, E
Rodriguez, AR
机构
[1] Commiss European Communities, Joint Res Ctr, Inst Reference Mat & Measurements, B-2440 Geel, Belgium
[2] Univ Liege, Fac Vet Med, Lab Anal Foodstuffs Anim Origin, B-4000 Liege, Belgium
[3] Univ Liege, Dept Chem, CART, B-4000 Liege, Belgium
关键词
antibiotics; fluoroquinolones; quinolones;
D O I
10.1016/S0021-9673(02)00092-4
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
New antibiotics were recently developed. among which are the (fluoro)quinolones. This paper presents an analytical method which allows the determination of 11 (fluoro)quinolones in swine kidneys: norfloxacin. ofloxacin. cinoxacin, oxolinic acid, nalidixic acid. flumequine, enrofloxacin, enoxacin. ciprofloxacin, danofloxacin and marbofloxacin. The procedure involves a rapid and efficient pre-treatment by solid-phase extraction (recoveries 83-98%), followed by the sensitive and selective determination of all compounds in a single run using LC-ESI-MS-MS. Multiple reaction monitoring (MPM) was used for selective detection of each (fluoro)quinolone. Quinine was selected as internal standard. The accuracy of the method. expressed as recovery, was between 89 and 109% the repeatability had a maximum RSD lower than 15%. The limits of detection (LOD) were much lower than the respective Maximum Residue Limits (MRL)/4. (C) 2002 Published by Elsevier Science B.V.
引用
收藏
页码:121 / 129
页数:9
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