microRNAs: tiny regulators of synapse function in development and disease

被引：52

作者：

Bicker, Silvia

Schratt, Gerhard ^{[1
]}

机构：

[1] Heidelberg Univ, Interdisziplinares Zentrum Neurowissensch, SFB488 Jr Grp, D-69120 Heidelberg, Germany

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2008年 / 12卷 / 5A期

关键词：

microRNA; nervous system; neuron; synapse; plasticity; dendritic spine; neurologic disease;

D O I：

10.1111/j.1582-4934.2008.00400.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The development and function of neuronal circuits within the brain are orchestrated by sophisticated gene regulatory mechanisms. Recently, microRNAs have emerged as a novel class of small RNAs that fine-tune protein synthesis. microRNAs are abundantly expressed in the vertebrate nervous system, where they contribute to the specification of neuronal cell identity. Moreover, microRNAs also play an important role in mature neurons. This review summarizes the current knowledge about the function of microRNAs in the nervous system with special emphasis on synapse formation and plasticity. The second part of this work will discuss the potential involvement of microRNAs in neurologic diseases. The study of brain microRNAs promises to expand our understanding of the mechanisms underlying higher cognitive functions and neurologic diseases.

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页码：1466 / 1476

页数：11

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