Quercetin and derivatives: useful tools in inflammation and pain management

被引：219

作者：

Carullo, Gabriele ^{[1
]}

Cappello, Anna Rita ^{[1
]}

Frattaruolo, Luca ^{[1
]}

Badolato, Mariateresa ^{[1
]}

Armentano, Biagio ^{[1
]}

Aiello, Francesca ^{[1
]}

机构：

[1] Univ Calabria, Dept Pharm Hlth & Nutr Sci, Via Pietro Bucci, I-87036 Rende Arcavacata, Cs, Italy

来源：

FUTURE MEDICINAL CHEMISTRY | 2017年 / 9卷 / 01期

关键词：

anti-inflammation activity; pain management; quercetin derivatives; NF-KAPPA-B; PROTECTS MOUSE-LIVER; ADIPOSE INFLAMMATION; FLAVONOID QUERCETIN; OXIDATIVE STRESS; IN-VITRO; ANTIOXIDANT; EXPRESSION; LIPOPOLYSACCHARIDE; ISORHAMNETIN;

D O I：

10.4155/fmc-2016-0186

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Inflammation represents a very frequent condition in humans; it is often underestimated, making the problem an increasingly alarming phenomenon. For these reasons, conventional therapies are losing their effectiveness, leaving room for innovative therapies. In this field, natural products showed their efficacy in various diseases; and flavonoids, in particular quercetin, is known for its broad range of activities. In this review, we have highlighted its efficacy in various models of inflammation, focusing also on the activity of its semisynthetic derivatives, and those naturally present in plant extracts. Finally, the analgesic property of quercetin, intrinsically linked to its anti-inflammatory action, has been also evaluated, to investigate about an innovative approach to this interesting natural compound, such as analgesic remedial.

引用

收藏

页码：79 / 93

页数：15

相关论文

共 108 条

[41]

Polyphenols: food sources, properties and applications - a review [J].

El Gharras, Hasna .

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 2009, 44 (12) :2512-2518

[42]

Immunomodulatory Effect of Red Onion (Allium cepa Linn) Scale Extract on Experimentally Induced Atypical Prostatic Hyperplasia in Wistar Rats [J].

Elberry, Ahmed A. ;

Mufti, Shagufta ;

Al-Maghrabi, Jaudah ;

Sattar, Essam Abdel ;

Ghareib, Salah A. ;

Mosli, Hisham A. ;

Gabr, Salah A. .

MEDIATORS OF INFLAMMATION, 2014, 2014

[43]

Red colouration in apple fruit is due to the activity of the MYB transcription factor, MdMYB10 [J].

Espley, Richard V. ;

Hellens, Roger P. ;

Putterill, Jo ;

Stevenson, David E. ;

Kutty-Amma, Sumathi ;

Allan, Andrew C. .

PLANT JOURNAL, 2007, 49 (03) :414-427

[44]

Dietary Flavonoids from Modified Apple Reduce Inflammation Markers and Modulate Gut Microbiota in Mice [J].

Espley, Richard V. ;

Butts, Christine A. ;

Laing, William A. ;

Martell, Sheridan ;

Smith, Hannah ;

McGhie, Tony K. ;

Zhang, Jingli ;

Paturi, Gunaranjan ;

Hedderley, Duncan ;

Bovy, Arnaud ;

Schouten, Henk J. ;

Putterill, Joanna ;

Allan, Andrew C. ;

Hellens, Roger P. .

JOURNAL OF NUTRITION, 2014, 144 (02) :146-154

[45]

Analgesic and antiinflammatory activities of the ethyl acetate fraction of Bidens pilosa (Asteraceae) [J].

Fotso, Aurelien ;

Longo, Frida ;

Djomeni, Paul Desire Dzeufiet ;

Kouam, Simeon Fogue ;

Spiteller, Michael ;

Dongmo, Alain Bertrand ;

Savineau, J. P. .

INFLAMMOPHARMACOLOGY, 2014, 22 (02) :105-114

[46]

Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress [J].

Fuerst, Robert ;

Zuendorf, Ilse .

MEDIATORS OF INFLAMMATION, 2014, 2014

[47]

Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis [J].

Gardi, C. ;

Bauerova, K. ;

Stringa, B. ;

Kuncirova, V. ;

Slovak, L. ;

Ponist, S. ;

Drafi, F. ;

Bezakova, L. ;

Tedesco, I. ;

Acquaviva, A. ;

Bilotto, S. ;

Russo, G. L. .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2015, 583 :150-157

[48]

Comparison of the Anti-inflammatory Effects of Proanthocyanidin, Quercetin, and Damnacanthal on Benzo(a)pyrene Exposed A549 Alveolar Cell Line [J].

Gunay, Ersin ;

Celik, Sefa ;

Sarinc-Ulasli, Sevinc ;

Ozyurek, Arzu ;

Hazman, Omer ;

Gunay, Sibel ;

Ozdemir, Mehmet ;

Unlu, Mehmet .

INFLAMMATION, 2016, 39 (02) :744-751

[49]

Quercetin and quercetin-3-O-glucuronide are equally effective in ameliorating endothelial insulin resistance through inhibition of reactive oxygen species-associated inflammation [J].

Guo, Xu-Dan ;

Zhang, Dong-Yan ;

Gao, Xue-Jiao ;

Parry, John ;

Liu, Kang ;

Liu, Bao-Lin ;

Wang, Min .

MOLECULAR NUTRITION & FOOD RESEARCH, 2013, 57 (06) :1037-1045

[50]

Anti-inflammatory effects of flavonoids:: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages [J].

Hamalainen, Mari ;

Nieminen, Riina ;

Vuorela, Pia ;

Heinonen, Marina ;

Moilanen, Eeva .

MEDIATORS OF INFLAMMATION, 2007, 2007

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