Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment

被引：238

作者：

Scheef, Lukas ^{[2
]}

Spottke, Annika ^{[1
,5
]}

Daerr, Moritz ^{[1
]}

Joe, Alexius ^{[4
]}

Striepens, Nadine ^{[1
]}

Koelsch, Heike ^{[1
]}

Popp, Julius ^{[1
,6
]}

Daamen, Marcel ^{[2
]}

Gorris, Dominik ^{[1
]}

Heneka, Michael T. ^{[3
,5
]}

Boecker, Henning ^{[2
,5
]}

Biersack, Hans J. ^{[4
]}

Maier, Wolfgang ^{[1
,5
]}

Schild, Hans H. ^{[2
]}

Wagner, Michael ^{[1
,5
]}

Jessen, Frank ^{[1
,5
]}

机构：

[1] Univ Bonn, Dept Psychiat, Bonn, Germany

[2] Univ Bonn, Dept Radiol, Bonn, Germany

[3] Univ Bonn, Dept Neurol, Clin Neurosci Unit, Bonn, Germany

[4] Univ Bonn, Dept Nucl Med, Bonn, Germany

[5] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[6] Univ Lausanne Hosp, Dept Psychiat, Lausanne, Switzerland

来源：

NEUROLOGY | 2012年 / 79卷 / 13期

关键词：

MILD COGNITIVE IMPAIRMENT; ALZHEIMERS ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; APOLIPOPROTEIN-E; DISEASE; COMPLAINTS; BIOMARKERS; VOLUME; RECOMMENDATIONS;

D O I：

10.1212/WNL.0b013e31826c1a8d

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To identify biological evidence for Alzheimer disease (AD) in individuals with subjective memory impairment (SMI) and unimpaired cognitive performance and to investigate the longitudinal cognitive course in these subjects. Method: [F-18]fluoro-2-deoxyglucose PET (FDG-PET) and structural MRI were acquired in 31 subjects with SMI and 56 controls. Cognitive follow-up testing was performed (average follow-up time: 35 months). Differences in baseline brain imaging data and in memory decline were assessed between both groups. Associations of memory decline with brain imaging data were tested. Results: The SMI group showed hypometabolism in the right precuneus and hypermetabolism in the right medial temporal lobe. Gray matter volume was reduced in the right hippocampus in the SMI group. At follow-up, subjects with SMI showed a poorer performance than controls on measures of episodic memory. Longitudinal memory decline in the SMI group was associated with reduced glucose metabolism in the right precuneus at baseline. Conclusion: The cross-sectional difference in 2 independent neuroimaging modalities indicates early AD pathology in SMI. The poorer memory performance at follow-up and the association of reduced longitudinal memory performance with hypometabolism in the precuneus at baseline support the concept of SMI as the earliest manifestation of AD. Neurology (R) 2012;79:1332-1339

引用

页码：1332 / 1339

页数：8

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