Synthesis of carbon-11 and fluorine-18 labeled N-acetyl-l-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolinederivatives as new potential PET AMPA receptor ligands

被引：50

作者：

Gao, M

Kong, DY

Clearfield, A

Zheng, QH ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA

[2] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 08期

关键词：

N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; derivatives; carbon-11; fluorine-18; positron emission tomography; 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid; receptor; brain diseases;

D O I：

10.1016/j.bmcl.2006.01.042

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives were designed and synthesized as potential positron emission tomography AMPA (2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid) receptor ligands to image brain diseases. The single crystal structure of the most potent compound N-acetyl-1-(4'-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (5a) is first reported. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2229 / 2233

页数：5

共 7 条

[1] Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers [J].