Palladium-catalysed enantioselective hydrogenation of alkenoic acids. Role of isomerization

被引：39

作者：

Borszeky, K ^{[1
]}

Mallat, T ^{[1
]}

Baiker, A ^{[1
]}

机构：

[1] ETH Zentrum, Swiss Fed Inst Technol, Tech Chem Lab, CH-8092 Zurich, Switzerland

来源：

CATALYSIS LETTERS | 1999年 / 59卷 / 2-4期

关键词：

enantioselective; hydrogenation; isomerization; cinchonidine; Pd alumina; alkenoic acid;

D O I：

10.1023/A:1019049311321

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The enantioselective hydrogenation of 2-ethyl-propenoic acid over Pd/alumina modified with cinchonidine has been studied. The reaction, carried out in a batch reactor at 1 bar hydrogen pressure and room temperature, revealed that the isomerization of the C=C double bond is a competing side reaction. Double-bond migration and the subsequent hydrogenation of the two isomer alkenoic acids lowered the enantioselectivity drastically due to the formation of opposite enantiomers.

引用

页码：95 / 97

页数：3

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