A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction

被引：121

作者：

Matsumoto, Sen ^{[1
]}

Sakata, Yasuhiko ^{[1
,2
,3
]}

Nakatani, Daisaku ^{[1
]}

Suna, Shinichiro ^{[1
]}

Mizuno, Hiroya ^{[1
,2
]}

Shimizu, Masahiko ^{[1
]}

Usami, Masaya ^{[1
]}

Sasaki, Tatsuya ^{[4
]}

Sato, Hiroshi ^{[5
]}

Kawahara, Yukio ^{[6
]}

Hamasaki, Toshimitsu ^{[7
]}

Nanto, Shinsuke ^{[1
,2
]}

Hori, Masatsugu ^{[8
]}

Komuro, Issei ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Cardiovasc Med, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Med, Dept Adv Cardiovasc Therapeut, Suita, Osaka 5650871, Japan

[3] Tohoku Univ, Grad Sch Med, Dept Evidenced Based Cardiovasc Med, Sendai, Miyagi 980, Japan

[4] Natl Hosp Org, Osaka Minami Med Ctr, Cardiovasc Div, Kawachi Nagano, Japan

[5] Kwansei Gakuin Univ, Hlth Care Ctr & Clin, Sch Human Wilfare Studies, Nishinomiya, Hyogo, Japan

[6] Osaka Univ, Grad Sch Med, Lab RNA Funct, Suita, Osaka 5650871, Japan

[7] Osaka Univ, Grad Sch Med, Dept Biomed Stat, Suita, Osaka 5650871, Japan

[8] Osaka Med Ctr Canc & Cardiovasc Dis, Osaka, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 427卷 / 02期

关键词：

Acute myocardial infarction; Circulating microRNAs; Secondary prevention; EXPRESSION; SERUM;

D O I：

10.1016/j.bbrc.2012.09.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

To investigate the prognostic impact of circulating microRNAs (miRs) in patients who survived acute myocardial infarction (AMI), we compared the circulating miR signature at the time of survival discharge among samples in the serum bank of the Osaka Acute Coronary Insufficiency Study. Using a high-throughput array consisting of 667 miRs, 11 miRs were found to be differentially expressed in the serum among patients at high-risk for cardiac death. Real-time RT-PCR confirmed that the serum levels of miR-155 and miR-380* were approximately 4- and 3-fold higher, respectively, in patients who experienced cardiac death within 1 year after discharge. Accordingly, a subset of circulating miRs might be predictive for cardiac death in post-AMI patients. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：280 / 284

页数：5

共 14 条

[1]

MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[2]

Circulating microRNAs are new and sensitive biomarkers of myocardial infarction [J].

D'Alessandra, Yuri ;

Devanna, Paolo ;

Limana, Federica ;

Straino, Stefania ;

Di Carlo, Anna ;

Brambilla, Paola G. ;

Rubino, Mara ;

Carena, Maria Cristina ;

Spazzafumo, Liana ;

De Simone, Marco ;

Micheli, Barbara ;

Biglioli, Paolo ;

Achilli, Felice ;

Martelli, Fabio ;

Maggiolini, Stefano ;

Marenzi, Giancarlo ;

Pompilio, Giulio ;

Capogrossi, Maurizio C. .

EUROPEAN HEART JOURNAL, 2010, 31 (22) :2765-2773

[3]

Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage [J].

Kuwabara, Yasuhide ;

Ono, Koh ;

Horie, Takahiro ;

Nishi, Hitoo ;

Nagao, Kazuya ;

Kinoshita, Minako ;

Watanabe, Shin ;

Baba, Osamu ;

Kojima, Yoji ;

Shizuta, Satoshi ;

Imai, Masao ;

Tamura, Toshihiro ;

Kita, Toru ;

Kimura, Takeshi .

CIRCULATION-CARDIOVASCULAR GENETICS, 2011, 4 (04) :446-U287

[4]

Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma [J].

Lawrie, Charles H. ;

Gal, Shira ;

Dunlop, Heather M. ;

Pushkaran, Beena ;

Liggins, Amanda P. ;

Pulford, Karen ;

Banham, Alison H. ;

Pezzella, Francesco ;

Boultwood, Jacqueline ;

Wainscoat, James S. ;

Hatton, Christian S. R. ;

Harris, Adrian L. .

BRITISH JOURNAL OF HAEMATOLOGY, 2008, 141 (05) :672-675

[5]

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44 [J].

Liu, Can ;

Kelnar, Kevin ;

Liu, Bigang ;

Chen, Xin ;

Calhoun-Davis, Tammy ;

Li, Hangwen ;

Patrawala, Lubna ;

Yan, Hong ;

Jeter, Collene ;

Honorio, Sofia ;

Wiggins, Jason F. ;

Bader, Andreas G. ;

Fagin, Randy ;

Brown, David ;

Tang, Dean G. .

NATURE MEDICINE, 2011, 17 (02) :211-U105

[6]

RETRACTED: MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts (Retracted Article) [J].

Martin, Mickey M. ;

Lee, Eun Joo ;

Buckenberger, Jessica A. ;

Schmittgen, Thomas D. ;

Elton, Terry S. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (27) :18277-18284

[7]

BASIC PRINCIPLES OF ROC ANALYSIS [J].

METZ, CE .

SEMINARS IN NUCLEAR MEDICINE, 1978, 8 (04) :283-298

[8]

Circulating microRNAs as stable blood-based markers for cancer detection [J].

Mitchell, Patrick S. ;

Parkin, Rachael K. ;

Kroh, Evan M. ;

Fritz, Brian R. ;

Wyman, Stacia K. ;

Pogosova-Agadjanyan, Era L. ;

Peterson, Amelia ;

Noteboom, Jennifer ;

O'Briant, Kathy C. ;

Allen, April ;

Lin, Daniel W. ;

Urban, Nicole ;

Drescher, Charles W. ;

Knudsen, Beatrice S. ;

Stirewalt, Derek L. ;

Gentleman, Robert ;

Vessella, Robert L. ;

Nelson, Peter S. ;

Martin, Daniel B. ;

Tewari, Muneesh .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (30) :10513-10518

[9]

Oral treatment with nicorandil at discharge is associated with reduced mortality after acute myocardial infarction [J].

Sakata, Yasuhiko ;

Nakatani, Daisaku ;

Shimizu, Masahiko ;

Suna, Shinichiro ;

Usami, Masaya ;

Matsumoto, Sen ;

Hara, Masahiko ;

Sumitsuji, Satoru ;

Kawano, Shigeo ;

Iwakura, Katsuomi ;

Hamasaki, Toshimitsu ;

Sato, Hiroshi ;

Nanto, Shinsuke ;

Hori, Masatsugu ;

Komuro, Issei .

JOURNAL OF CARDIOLOGY, 2012, 59 (01) :14-21

[10]

p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload [J].

Sano, Masanori ;

Minamino, Tohru ;

Toko, Haruhiro ;

Miyauchi, Hideyuki ;

Orimo, Masayuki ;

Qin, Yingjie ;

Akazawa, Hiroshi ;

Tateno, Kaoru ;

Kayama, Yosuke ;

Harada, Mutsuo ;

Shimizu, Ippei ;

Asahara, Takayuki ;

Hamada, Hirofumi ;

Tomita, Shuhei ;

Molkentin, Jeffrey D. ;

Zou, Yunzeng ;

Komuro, Issei .

NATURE, 2007, 446 (7134) :444-448

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