Design Strategy for DNA Rotaxanes with a Mechanically Reinforced PX100 Axle

被引:38
作者
Ackermann, Damian [1 ]
Jester, Stefan-S.
Famulok, Michael [1 ]
机构
[1] Univ Bonn, LIMES Inst, Chem Biol & Med Chem Unit, Kekule Inst Organ Chem & Biochem, Gerhard Domagk Str 1, D-53121 Bonn, Germany
基金
欧洲研究理事会;
关键词
DNA nanorings; DNA nanotechnology; DNA rotaxanes; paranemic crossover; pseudorotaxanes; DOUBLE-CROSSOVER MOLECULES; PARANEMIC CROSSOVER; FOLDING DNA; NANOTECHNOLOGY; ORIGAMI; MOTORS; MACHINES; NANOSTRUCTURES; NANOMECHANICS; ARCHITECTURES;
D O I
10.1002/anie.201202816
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Non-deformable axles based on paranemic crossover DNAs can serve as components for mechanically stable DNA rotaxanes. The required design strategies provide generally applicable guidelines for the incorporation of mechanically interlocked DNA architectures or even DNA origami structures. DNA rotaxanes with mechanically reinforced axles can serve as precursors for complex molecular machines capable of force transmission. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:6771 / 6775
页数:5
相关论文
共 63 条
[41]   Structural Rigidity of Paranemic Crossover and Juxtapose DNA Nanostructures [J].
Santosh, Mogurampelly ;
Maiti, Prabal K. .
BIOPHYSICAL JOURNAL, 2011, 101 (06) :1393-1402
[42]   Transition metal-containing rotaxanes and catenanes in motion: Toward molecular machines and motors [J].
Sauvage, JP .
ACCOUNTS OF CHEMICAL RESEARCH, 1998, 31 (10) :611-619
[43]   On the way to rotaxane-based molecular motors:: Studies in molecular mobility and topological chirality [J].
Schalley, CA ;
Beizai, K ;
Vögtle, F .
ACCOUNTS OF CHEMICAL RESEARCH, 2001, 34 (06) :465-476
[44]  
Schmidt T. L., 2007, ANGEW CHEM, V119, P4460
[45]   Polyamide struts for DNA architectures [J].
Schmidt, Thorsten L. ;
Nandi, Chayan K. ;
Rasched, Goran ;
Parui, Partha P. ;
Brutschy, Bernd ;
Famulok, Michael ;
Heckel, Alexander .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (23) :4382-4384
[46]   Nanomaterials Based on DNA [J].
Seeman, Nadrian C. .
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79, 2010, 79 :65-87
[47]   DNA in a material world [J].
Seeman, NC .
NATURE, 2003, 421 (6921) :427-431
[48]   Paranemic crossover DNA: A generalized Holliday structure with applications in nanotechnology [J].
Shen, ZY ;
Yan, H ;
Wang, T ;
Seeman, NC .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (06) :1666-1674
[49]   Knitting complex weaves with DNA origami [J].
Shih, William M. ;
Lin, Chenxiang .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2010, 20 (03) :276-282
[50]  
Simmel F. C., 2012, CURR OPIN BIOTECH, DOI [10.1016/j.copbio.2011.1012.1024, DOI 10.1016/J.COPBIO.2011.1012.1024