Chemogenomics: An emerging strategy for rapid target and drug discovery

被引:268
作者
Bredel, M
Jacoby, E
机构
[1] Stanford Univ, Div Oncol, Sch Med, Stanford, CA 94305 USA
[2] Univ Freiburg, Neuroctr, Dept Gen Neurosurg, D-79106 Freiburg, Germany
[3] Novartis Inst Biomed Res, Discovery Technol Mol & Lib Informat Program, CH-4002 Basel, Switzerland
关键词
D O I
10.1038/nrg1317
中图分类号
Q3 [遗传学];
学科分类号
071007 [遗传学]; 090102 [作物遗传育种];
摘要
Chemogenomics is an emerging discipline that combines the latest tools of genomics and chemistry and applies them to target and drug discovery. Its strength lies in eliminating the bottleneck that currently occurs in target identification by measuring the broad, conditional effects of chemical libraries on whole biological systems or by screening large chemical libraries quickly and efficiently against selected targets. The hope is that chemogenomics will concurrently identify and validate therapeutic targets and detect drug candidates to rapidly and effectively generate new treatments for many human diseases.
引用
收藏
页码:262 / 275
页数:14
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