One-pot synthesis and antibacterial activities of pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine-dione derivatives

被引：102

作者：

Bazgir, Ayoob ^{[1
]}

Khanaposhtani, Maryam Mohammadi ^{[1
]}

Soorki, Ali Abolhasani ^{[2
]}

机构：

[1] Shahid Beheshti Univ, Dept Chem, Tehran, Iran

[2] Shahid Beheshti Univ, Acad Ctr Educ Culture & Res, Res Inst Petr, Tehran, Iran

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 21期

关键词：

1H-Pyrazol-5-amines; Barbituric acid; Pyrimidopyrimidine; Thiobarbituric acid; Pyrazolopyrimidine;

D O I：

10.1016/j.bmcl.2008.09.057

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A one-pot and efficient method for the synthesis of pyrazolo[4',3':5,6] pyrido[2,3-d]pyrimidine-dione derivatives by condensation reaction of barbituric acids, 1H-pyrazol-5-amines and aldehydes under solvent-free conditions is reported. These products were evaluated in vitro for their antibacterial activities. (C) 2008 Published by Elsevier Ltd.

引用

页码：5800 / 5803

页数：4

共 26 条

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