microRNAs and muscle disorders

被引:114
作者
Chen, Jian-Fu
Callis, Thomas E.
Wang, Da-Zhi [1 ]
机构
[1] Univ N Carolina, Carolina Cardiovasc Biol Ctr, Chapel Hill, NC 27599 USA
基金
美国国家卫生研究院;
关键词
microRNA; Cardiac muscle; Skeletal muscle; Cardiac hypertrophy; Cardiomyopathy; Gene regulation; Muscle disease; CARDIAC-HYPERTROPHY; HEART-FAILURE; CAENORHABDITIS-ELEGANS; SKELETAL MYOGENESIS; C-ELEGANS; IN-VIVO; EXPRESSION; DIFFERENTIATION; TARGETS; MOUSE;
D O I
10.1242/jcs.041723
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
MicroRNAs (miRNAs) are a class of non-coding regulatory RNAs of similar to 22 nucleotides in length. miRNAs are highly conserved across a number of species, including plants, worms and humans. miRNAs regulate gene expression post-transcriptionally, primarily by associating with the 3' untranslated region (UTR) of their regulatory target mRNAs. Recent work has begun to reveal roles for miRNAs in a wide range of biological processes, including cell proliferation, differentiation and apoptosis. miRNAs are expressed in cardiac and skeletal muscle, and dysregulated miRNA expression has been correlated with muscle-related disorders. Genetic studies have identified distinct roles for specific miRNAs during cardiogenesis, cardiac hypertrophy and electrical conduction. Furthermore, conditionally inhibiting the maturation of miRNAs in mouse cardiac and skeletal muscles has revealed that miRNAs are essential for the development and function of those muscles. These previously unrecognized regulators shed new light on the molecular mechanisms that underlie muscle development and pathology, and suggest the potential importance of miRNAs as diagnostic markers and therapeutic targets for muscle-related disease.
引用
收藏
页码:13 / 20
页数:8
相关论文
共 77 条
[1]   The genetic basis for cardiac remodeling [J].
Ahmad, F ;
Seidman, JG ;
Seidman, CE .
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2005, 6 :185-216
[2]   The functions of animal microRNAs [J].
Ambros, V .
NATURE, 2004, 431 (7006) :350-355
[3]   MIR-206 regulates connexin43 expression during skeletal muscle development [J].
Anderson, Curtis ;
Catoe, Heath ;
Werner, Rudolf .
NUCLEIC ACIDS RESEARCH, 2006, 34 (20) :5863-5871
[4]  
[Anonymous], YALE J BIOL MED
[5]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29
[6]   Diversity of microRNAs in human and chimpanzee brain [J].
Berezikov, Eugene ;
Thuemmler, Fritz ;
van Laake, Linda W. ;
Kondova, Ivanela ;
Bontrop, Ronald ;
Cuppen, Edwin ;
Plasterk, Ronald H. A. .
NATURE GENETICS, 2006, 38 (12) :1375-1377
[7]   ECM remodeling in hypertensive heart disease [J].
Berk, Bradford C. ;
Fujiwara, Keigi ;
Lehoux, Stephanie .
JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (03) :568-575
[8]   Dicer is essential for mouse development [J].
Bernstein, E ;
Kim, SY ;
Carmell, MA ;
Murchison, EP ;
Alcorn, H ;
Li, MZ ;
Mills, AA ;
Elledge, SJ ;
Anderson, KV ;
Hannon, GJ .
NATURE GENETICS, 2003, 35 (03) :215-217
[9]   MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development [J].
Boutz, Paul L. ;
Chawla, Geetanjali ;
Stoilov, Peter ;
Black, Douglas L. .
GENES & DEVELOPMENT, 2007, 21 (01) :71-84
[10]   bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila [J].
Brennecke, J ;
Hipfner, DR ;
Stark, A ;
Russell, RB ;
Cohen, SM .
CELL, 2003, 113 (01) :25-36