Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial

被引：179

作者：

Bahadoran, Zahra ^{[2
]}

Tohidi, Maryam ^{[3
]}

Nazeri, Pantea ^{[2
]}

Mehran, Mahya ^{[2
]}

Azizi, Fereidoun ^{[4
]}

Mirmiran, Parvin ^{[1
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Clin Nutr & Diet Therapy, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Obes Res Ctr, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Prevent Metab Disorders Res Ctr, Tehran, Iran

[4] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran

来源：

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION | 2012年 / 63卷 / 07期

关键词：

type; 2; diabetes; insulin resistance; broccoli sprouts; sulphoraphane; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; DIETARY;

D O I：

10.3109/09637486.2012.665043

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Use of antioxidant components is a new approach for improvement of insulin resistance (IR) as a main feature of type 2 diabetes and its complications. The aim of this study was to investigate the effects of broccoli sprouts powder (BSP) containing high concentration of sulphoraphane on IR in type 2 diabetic patients. Eighty-one patients were randomly assigned to receive 10 g/d BSP (A, n = 27), 5 g/d BSP (B, n = 29) and placebo (C, n = 25) for 4 weeks. Fasting serum glucose and insulin concentration, glucose to insulin ratio and homoeostasis model assessment of IR (HOMA-IR) index were measured at baseline and again 4 weeks after treatment. Seventy-two patients completed the study and 63 were included in the analysis. After 4 weeks, consumption of 10 g/d BSP resulted in a significant decrease in serum insulin concentration and HOMA-IR (p = 0.05 for treatment effect). Therefore, broccoli sprouts may improve IR in type 2 diabetic patients.

引用

页码：767 / 771

页数：5

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