Isolation and structure elucidation of a novel antimalarial macrocyclic polylactone, menisporopsin A, from the fungus Menisporopsis theobromae

被引：35

作者：

Chinworrungsee, M

Kittakoop, P ^{[1
]}

Isaka, M

Maithip, P

Supothina, S

Thebtaranonth, Y

机构：

[1] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand

[2] NSTDA, Natl Ctr Genet Engn & Biotechnol, BIOTEC, Pathum Thani 12120, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 04期

关键词：

D O I：

10.1021/np0304870

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

An antimalarial macrocyclic polylactone, menisporopsin A (1), was isolated from a cell extract of the seed fungus Menisporopsis theobromae. The structure of 1 was elucidated on the basis of spectroscopic analysis and chemical transformations, with the absolute configuration established by application of the modified Mosher method and by using chiral HPLC. Menisporopsin A (1) possesses an unprecedented residue, 2,4-dihydroxy-6-(2,4-dihydroxy-n-pentyl)benzoic acid. This compound exhibited antimalarial activity, with an IC50 value of 4.0 mug mL(-1), and antimycobacterial activity (MIC value of 50 mug mL(-1)).

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收藏

页码：689 / 692

页数：4

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