Nucleocytoplasmic shuttling of signal transducers

被引：215

作者：

Xu, L ^{[1
]}

Massagué, A

机构：

[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

[2] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 03期

关键词：

D O I：

10.1038/nrm1331

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The nuclear translocation of signal-transduction proteins is an essential step in the control of gene expression by numerous extracellular signals. Recent studies have shown that some signal transducers are imported into the nucleus by nuclear-localization-signal- and importin-independent processes. Such a mechanism could allow bidirectional movement across the nuclear envelope. Extracellular signals modify the affinity between signal transducers and anchoring factors, thereby regulating the nucleocytoplasmic shuttling of signalling molecules.

引用

页码：209 / 219

页数：11

共 144 条

[11] Importin β contains a COOH-terminal nucleoporin binding region important for nuclear transport [J].

Bednenko, J ;

Cingolani, G ;

Gerace, L .

JOURNAL OF CELL BIOLOGY, 2003, 162 (03) :391-401

[12]

BEG AA, 1992, GENE DEV, V6, P2664

[13] Gradient of increasing affinity of importin β for nucleoporins along the pathway of nuclear import [J].

Ben-Efraim, I ;

Gerace, L .

JOURNAL OF CELL BIOLOGY, 2001, 152 (02) :411-417

[14] CATALYSIS OF GUANINE-NUCLEOTIDE EXCHANGE ON RAN BY THE MITOTIC REGULATOR RCC1 [J].

BISCHOFF, FR ;

PONSTINGL, H .

NATURE, 1991, 354 (6348) :80-82

[15] RANGAP1 INDUCED GTPASE ACTIVITY OF NUCLEAR RAS-RELATED RAN [J].

BISCHOFF, FR ;

KLEBE, C ;

KRETSCHMER, J ;

WITTINGHOFER, A ;

PONSTINGL, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (07) :2587-2591

[16] COACTIVATION OF RANGTPASE AND INHIBITION OF GTP DISSOCIATION BY RAN GTP-BINDING PROTEIN RANBP1 [J].

BISCHOFF, FR ;

KREBBER, H ;

SMIRNOVA, E ;

DONG, WH ;

PONSTINGL, H .

EMBO JOURNAL, 1995, 14 (04) :705-715

[17] A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase [J].

Blanco-Aparicio, C ;

Torres, J ;

Pulido, R .

JOURNAL OF CELL BIOLOGY, 1999, 147 (06) :1129-1135

[18]

Bogerd HP, 1996, MOL CELL BIOL, V16, P4207

[19] AN INSULIN-STIMULATED PROTEIN-KINASE SIMILAR TO YEAST KINASES INVOLVED IN CELL-CYCLE CONTROL [J].

BOULTON, TG ;

YANCOPOULOS, GD ;

GREGORY, JS ;

SLAUGHTER, C ;

MOOMAW, C ;

HSU, J ;

COBB, MH .

SCIENCE, 1990, 249 (4964) :64-67

[20] ERKS - A FAMILY OF PROTEIN-SERINE THREONINE KINASES THAT ARE ACTIVATED AND TYROSINE PHOSPHORYLATED IN RESPONSE TO INSULIN AND NGF [J].

BOULTON, TG ;

NYE, SH ;

ROBBINS, DJ ;

IP, NY ;

RADZIEJEWSKA, E ;

MORGENBESSER, SD ;

DEPINHO, RA ;

PANAYOTATOS, N ;

COBB, MH ;

YANCOPOULOS, GD .

CELL, 1991, 65 (04) :663-675

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