Nucleocytoplasmic shuttling of signal transducers

被引：215

作者：

Xu, L ^{[1
]}

Massagué, A

机构：

[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

[2] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 03期

关键词：

D O I：

10.1038/nrm1331

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The nuclear translocation of signal-transduction proteins is an essential step in the control of gene expression by numerous extracellular signals. Recent studies have shown that some signal transducers are imported into the nucleus by nuclear-localization-signal- and importin-independent processes. Such a mechanism could allow bidirectional movement across the nuclear envelope. Extracellular signals modify the affinity between signal transducers and anchoring factors, thereby regulating the nucleocytoplasmic shuttling of signalling molecules.

引用

页码：209 / 219

页数：11

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