Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions

被引：3564

作者：

Pearson, G ^{[1
]}

Robinson, F ^{[1
]}

Gibson, TB ^{[1
]}

Xu, BE ^{[1
]}

Karandikar, M ^{[1
]}

Berman, K ^{[1
]}

Cobb, MH ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA

来源：

ENDOCRINE REVIEWS | 2001年 / 22卷 / 02期

关键词：

D O I：

10.1210/er.22.2.153

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases Lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2.

引用

页码：153 / 183

页数：31

共 449 条

[1] c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1 (BMK1) [J].

Abe, J ;

Takahashi, M ;

Ishida, M ;

Lee, JD ;

Berk, BC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (33) :20389-20394

[2] Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase [J].

Abe, J ;

Kusuhara, M ;

Ulevitch, RJ ;

Berk, BC ;

Lee, JD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (28) :16586-16590

[3]

Abe MK, 1999, MOL CELL BIOL, V19, P1301

[4]

Abe S, 1995, ONCOGENE, V11, P2187

[5] Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer [J].

Adachi, M ;

Fukuda, M ;

Nishida, E .

EMBO JOURNAL, 1999, 18 (19) :5347-5358

[6]

AHN NG, 1991, J BIOL CHEM, V266, P4220

[7]

AHN NG, 1990, J BIOL CHEM, V265, P11495

[8]

Akada R, 1996, GENETICS, V143, P103

[9]

Akashi M, 2000, GENE DEV, V14, P645

[10]

ALESSI DR, 1993, ONCOGENE, V8, P2015

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