Nucleocytoplasmic shuttling of signal transducers

被引：215

作者：

Xu, L ^{[1
]}

Massagué, A

机构：

[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

[2] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 03期

关键词：

D O I：

10.1038/nrm1331

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The nuclear translocation of signal-transduction proteins is an essential step in the control of gene expression by numerous extracellular signals. Recent studies have shown that some signal transducers are imported into the nucleus by nuclear-localization-signal- and importin-independent processes. Such a mechanism could allow bidirectional movement across the nuclear envelope. Extracellular signals modify the affinity between signal transducers and anchoring factors, thereby regulating the nucleocytoplasmic shuttling of signalling molecules.

引用

页码：209 / 219

页数：11

共 144 条

[41] EMBRYONIC AXIS INDUCTION BY THE ARMADILLO REPEAT DOMAIN OF BETA-CATENIN - EVIDENCE FOR INTRACELLULAR SIGNALING [J].

FUNAYAMA, N ;

FAGOTTO, F ;

MCCREA, P ;

GUMBINER, BM .

JOURNAL OF CELL BIOLOGY, 1995, 128 (05) :959-968

[42] Casein kinase I phosphorylates and destabilizes the β-catenin degradation complex [J].

Gao, ZH ;

Seeling, JM ;

Hill, V ;

Yochum, A ;

Virshup, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) :1182-1187

[43] The MDM2 RING-finger domain is required to promote p53 nuclear export [J].

Geyer, RK ;

Yu, ZK ;

Maki, CG .

NATURE CELL BIOLOGY, 2000, 2 (09) :569-573

[44] Caught up in a Wnt storm: Wnt signaling in cancer [J].

Giles, RH ;

van Es, JH ;

Clevers, H .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2003, 1653 (01) :1-24

[45] ISOLATION OF A PROTEIN THAT IS ESSENTIAL FOR THE FIRST STEP OF NUCLEAR-PROTEIN IMPORT [J].

GORLICH, D ;

PREHN, S ;

LASKEY, RA ;

HARTMANN, E .

CELL, 1994, 79 (05) :767-778

[46] Identification of different roles for RanGDP and RanGTP in nuclear protein import [J].

Gorlich, D ;

Pante, N ;

Kutay, U ;

Aebi, U ;

Bischoff, FR .

EMBO JOURNAL, 1996, 15 (20) :5584-5594

[47] Crystal structure of a β-catenin/Tcf complex [J].

Graham, TA ;

Weaver, C ;

Mao, F ;

Kimelman, D ;

Xu, WQ .

CELL, 2000, 103 (06) :885-896

[48] Identification of p53 sequence elements that are required for MDM2-mediated nuclear export [J].

Gu, JJ ;

Nie, LH ;

Wiederschain, D ;

Yuan, ZM .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (24) :8533-8546

[49] Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain [J].

Gu, W ;

Roeder, RG .

CELL, 1997, 90 (04) :595-606

[50] ALPHA-FORMS AND BETA-FORMS OF THE 65-KDA SUBUNIT OF PROTEIN PHOSPHATASE-2A HAVE A SIMILAR 39 AMINO-ACID REPEATING STRUCTURE [J].

HEMMINGS, BA ;

ADAMSPEARSON, C ;

MAURER, F ;

MULLER, P ;

GORIS, J ;

MERLEVEDE, W ;

HOFSTEENGE, J ;

STONE, SR .

BIOCHEMISTRY, 1990, 29 (13) :3166-3173

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