Spot the differences: proteomics in cancer research

被引：34

作者：

Lawrie, Laura C. ^{[1
]}

Fothergill, John E. ^{[1
]}

Murray, Graeme, I ^{[2
]}

机构：

[1] Univ Aberdeen, Dept Mol & Cell Biol, Aberdeen, Scotland

[2] Univ Aberdeen, Pathol, Aberdeen, Scotland

来源：

LANCET ONCOLOGY | 2001年 / 2卷 / 05期

关键词：

D O I：

10.1016/S1470-2045(00)00321-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Separation of thousands of cellular proteins by two-dimensional electrophoresis allows the detailed comparison of proteins from normal and diseased tissue. Mass spectrometry provides a fast and reliable way of characterising proteins of interest, particularly when the gene sequence of the source organism is known. The availability of the human genome sequence has opened up the possibility of identifying protein differences between normal and diseased tissue, thus providing the opportunity to search for tumour markers or for therapeutic targets. This new technology will give much-needed insight into the molecular mechanisms of tumour development and progression.

引用

页码：270 / 277

页数：8

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