Aspergillus niger catalyzes the synthesis of flavonoids from chalcones

被引：22

作者：

Alarcon, Julio ^{[1
]}

Alderete, Joel ^{[2
]}

Escobar, Carlos ^{[3
]}

Araya, Ramiro ^{[4
]}

Cespedes, Carlos L. ^{[1
]}

机构：

[1] Univ Bio Bio, Lab Sintesis & Biotransformac Prod Nat, Dept Ciencias Basicas, Chillan, Chile

[2] Univ Concepcion, Dept Quim Organ, Concepcion, Chile

[3] Univ Chile, Fac Ciencias, Dept Quim Organ, Santiago, Chile

[4] Univ Nacl Andres, Santiago, Chile

来源：

BIOCATALYSIS AND BIOTRANSFORMATION | 2013年 / 31卷 / 04期

关键词：

A; niger; chalcones biotransformation; flavonoids; MICROBIAL TRANSFORMATIONS; BIOTRANSFORMATION; FLAVANONE;

D O I：

10.3109/10242422.2013.813489

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Flavonoids, which have many biological activities and have been widely used in nature, can be artificially synthesized. However, regioselective cyclization of chalcones is difficult by chemical methods. In this study, we demonstrated that Aspergillus niger is capable of cyclizing chalcones to flavanones, affording a mimic of plant biosynthetic processes. Chalcones 1-6 were biotransformated to the modified chalcones 8-14 and to the flavanones 15-27. The biotransformation showed that enzymatic cyclization and demethylation occurred during the first days of biotransformation; in contrast, hydroxylation is a later process. With a longer culturing time, it is possible to obtain more hydroxylated flavanones with excellent yields.

引用

页码：160 / 167

页数：8

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