Enzymatic evaluation of different Aspergillus strains by biotransformation of cyclic ketones

被引：19

作者：

Keppler, AF

Porto, ALM

Schoenlein-Crusius, IH

Comasseto, JV

Andrade, LH

机构：

[1] Univ Sao Paulo, Inst Quim, Lab Quim Fina & Biocatalise, BR-05508900 Sao Paulo, Brazil

[2] Inst Bot, Secao Micol & Liquenol, BR-01061970 Sao Paulo, Brazil

来源：

ENZYME AND MICROBIAL TECHNOLOGY | 2005年 / 36卷 / 07期

基金：

巴西圣保罗研究基金会;

关键词：

biotransformation; Baeyer-Villiger; bioreduction; Aspergillus;

D O I：

10.1016/j.enzmictec.2005.01.024

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

The potential of different Aspergillus strains in carrying out the biotransformation of cyclic ketones was investigated. All the strains employed showed alcohol dehydrogenase and Baeyer-Villiger monooxygenase activities. trans-2-Methylcyclohexanol and trans-4-methylcyclohexanol were prepared in a single isomeric form by the use of Aspergillus terreus SSP 1498 and the corresponding ketones. Baeyer-Villiger oxidation of cyclic ketones by all the fungi Aspergillus led to chiral lactones in good enantio selectivity. (c) 2005 Elsevier Inc. All rights reserved.

引用

收藏

页码：967 / 975

页数：9

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