New advances of DNA methylation in liver fibrosis, with special emphasis on the crosstalk between microRNAs and DNA methylation machinery

被引：39

作者：

Bian, Er-Bao ^{[1
,2
]}

Zhao, Bing ^{[3
]}

Huang, Cheng ^{[1
,2
]}

Wang, Hua ^{[1
,2
]}

Meng, Xiao-Ming ^{[1
,2
]}

Wu, Bao-Ming ^{[1
,2
]}

Ma, Tao-Tao ^{[2
]}

Zhang, Lei ^{[2
]}

Lv, Xiong-Wen ^{[2
]}

Li, Jun ^{[1
,2
]}

机构：

[1] Anhui Med Univ, Inst Liver Dis, Hefei, Peoples R China

[2] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China

[3] Anhui Med Univ, Affiliated Hosp 2, Dept Neurosurg, Hefei 230601, Peoples R China

来源：

CELLULAR SIGNALLING | 2013年 / 25卷 / 09期

基金：

美国国家科学基金会;

关键词：

Liver fibrosis; Hepatic stellate cell (HSC); DNA methylation; microRNA; MeCP2; HEPATIC STELLATE CELL; NF-KAPPA-B; TUMOR-SUPPRESSOR GENE; DOWN-REGULATION; MYOFIBROBLAST TRANSDIFFERENTIATION; TRANSCRIPTIONAL REGULATION; HEPATOCELLULAR-CARCINOMA; MECP2; CONTROLS; TET PROTEINS; EXPRESSION;

D O I：

10.1016/j.cellsig.2013.05.017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Epigenetics refers to the study of heritable changes in the pattern of gene expression that is controlled by a mechanism specifically not due to changes the primary DNA sequence. Well-known epigenetic mechanisms include DNA methylation, post-translational histone modifications and RNA-based mechanisms including those controlled by small non-coding RNAs (miRNAs). Recent studies have shown that epigenetic modifications orchestrate the hepatic stellate cell (HSC) activation and liver fibrosis. In this review we focus on the aberrant methylation of CpG island promoters of select genes is the prominent epigenetic mechanism to effectively silence gene transcription facilitating HSC activation and liver fibrosis. Furthermore, we also discuss epigenetic dysregulation of tumor-suppressor miRNA genes by promoter DNA methylation and the interaction of DNA methylation with miRNAs involved in the regulation of HSC activation and liver fibrosis. Recent advances in epigenetics alterations in the pathogenesis of liver fibrosis and their possible use as new therapeutic targets and biomarkers. (c) 2013 The Authors. Published by Elsevier Inc. All rights reserved.

引用

页码：1837 / 1844

页数：8

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