Pd Nanosheet-Covered Hollow Mesoporous Silica Nanoparticles as a Platform for the Chemo-Photothermal Treatment of Cancer Cells

被引：261

作者：

Fang, Weijun ^{[1
,2
]}

Tang, Shaoheng ^{[1
,2
]}

Liu, Pengxin ^{[1
,2
]}

Fang, Xiaoliang ^{[1
,2
]}

Gong, Jiawei ^{[1
,2
]}

Zheng, Nanfeng ^{[1
,2
]}

机构：

[1] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China

来源：

SMALL | 2012年 / 8卷 / 24期

关键词：

chemotherapy; photothermal therapy; mesoporous silica; Pd nanosheets; nanocomposites; WALLED CARBON NANOTUBES; MULTIFUNCTIONAL NANOPARTICLES; GOLD NANOPARTICLES; GRAPHENE OXIDE; DRUG-DELIVERY; THERAPY; ABLATION; NANOCRYSTALS; RELEASE; NANORODS;

D O I：

10.1002/smll.201200962

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A versatile system combining chemotherapy with photothermal therapy for cancer cells using Pd nanosheet-covered hollow mesoporous silica nanoparticles is reported. While the hollow mesoporous silica core can be used to load anticancer drugs (i.e., doxorubicin) for chemotherapy, the Pd nanosheets on the surface of particles can convert NIR light into heat for photothermal therapy. More importantly, the loading of Pd nanosheets on hollow mesoporous silica nanospheres can dramatically increase the amount of cellular internalization of the Pd nanosheets: almost 11 times higher than the unloaded Pd nanosheets. The as-prepared nanocomposites efficiently deliver both drugs and heat to cancer cells to improve the therapeutic efficiency with minimal side effects. Compared with chemotherapy or photothermal therapy alone, the combination of chemotherapy and phototherapy can significantly improve the therapeutic efficacy, exhibiting a synergistic effect.

引用

页码：3816 / 3822

页数：7

共 46 条

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Thermal ablation of tumor cells with anti body-functionalized single-walled carbon nanotubes [J].