Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B

被引：40

作者：

Fresneda, PM

Delgado, S

Francesch, A

Manzanares, I

Cuevas, C

Molina, P

机构：

[1] Univ Murcia, Dept Quim Organ, Fac Quim, E-30100 Murcia, Spain

[2] PharmaMar SA, Madrid 28770, Spain

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 49卷 / 03期

关键词：

D O I：

10.1021/jm051090r

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The marine alkaloid variolin B 2 and eight synthetic derivatives with different substituents at positions C-5 and C-7 have been tested in a panel of sixteen human tumor cell lines to evaluate their cytotoxic potential.

引用

页码：1217 / 1221

页数：5

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