The mystery of mitochondrial RNases

被引:10
作者
Bruni, Francesco [1 ]
Gramegna, Pasqua [1 ]
Lightowlers, Robert N. [1 ,2 ]
Chrzanowska-Lightowlers, Zofia M. A. [1 ]
机构
[1] Newcastle Univ, Sch Med, Wellcome Trust Ctr Mitochondrial Res, Mitochondrial Res Grp,Inst Ageing & Hlth, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
[2] Newcastle Univ, Sch Med, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
基金
英国惠康基金; 英国生物技术与生命科学研究理事会;
关键词
deadenylation; degradation; mitochondrion; mRNA; RNase; POLYNUCLEOTIDE PHOSPHORYLASE; MESSENGER-RNAS; SUBCELLULAR-LOCALIZATION; MAMMALIAN MITOCHONDRIA; POLY(A) POLYMERASE; DNA-REPLICATION; LAGGING-STRAND; ENDONUCLEASE-G; ENCODED RNA; PROTEINS;
D O I
10.1042/BST20120022
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The central dogma states that DNA is transcribed to generate RNA and that the mRNA components are then translated to generate proteins; a simple statement that completely belies the complexities of gene expression. Post-transcriptional regulation alone has many points of control, including changes in the stability, translatability or susceptibility to degradation of RNA species, where both cis- and transacting elements will play a role in the outcome. The present review concentrates on just one aspect of this complicated process, which ultimately regulates the protein production in cells, or more specifically what governs RNA catabolism in a particular subcompartment of human cells: the mitochondrion.
引用
收藏
页码:865 / 869
页数:5
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