De-racemization of Enantiomers versus De-epimerization of Diastereomers-Classification of Dynamic Kinetic Asymmetric Transformations (DYKAT)

被引：233

作者：

Steinreiber, Johannes ^{[1
]}

Faber, Kurt ^{[2
]}

Griengl, Herfried ^{[1
,3
]}

机构：

[1] Res Ctr Appl Biocatalysis, A-8010 Graz, Austria

[2] Graz Univ, Inst Chem, A-8010 Graz, Austria

[3] Graz Univ Technol, Inst Organ Chem, A-8010 Graz, Austria

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2008年 / 14卷 / 27期

关键词：

asymmetric synthesis; de-epimerization; de-racemization; dynamic kinetic asymmetric transformations; dynamic kinetic resolution;

D O I：

10.1002/chem.200701643

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The isolation of single stereoisomers from a racemic (or diastereomeric) mixture by enzymatic or chemical resolution techniques goes in hand with the disposal of 50% (racemate) or more (diastereomeric mixtures) of the "undesired" substrate isomer(s). In order to circumvent this drawback, dynamic systems have been developed for the de-racemization of enantiomers and the de-epimerizations of diastereomers. Key strategies within this area are discussed and are classified according to their underlying kinetics, that is, dynamic kinetic resolution (DKR), dynamic kinetic asymmetric transformations (DYKAT), and hybrids between both of them. Finally, two novel types of DYKAT are defined.

引用

页码：8060 / 8072

页数：13

共 113 条

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