A study of asymmetric hydrocyanation of heteroaryl carboxaldehydes catalyzed by (R)-oxynitrilase under micro-aqueous conditions

被引：24

作者：

Chen, PR ^{[1
]}

Han, SQ ^{[1
]}

Lin, GQ ^{[1
]}

Huang, H ^{[1
]}

Li, ZY ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 23期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0957-4166(02)00005-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A number of new optically active heteroaryl cyanohydrins have been prepared by hydrocyanation under micro-aqueous conditions catalyzed by almond meal (containing (R)-oxynitrilase). Substituent effects on the reaction are discussed. This micro-aqueous method provides an efficient, convenient and economical approach to optically active cyanohydrins. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：3273 / 3279

页数：7

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