DNA methylation profiling in the clinic: applications and challenges

被引：585

作者：

Heyn, Holger ^{[1
]}

Esteller, Manel ^{[1
,2
,3
]}

机构：

[1] Bellvitge Biomed Res Inst IDIBELL, Canc Epigenet & Biol Program PEBC, Barcelona 08908, Catalonia, Spain

[2] Univ Barcelona, Sch Med, Dept Physiol Sci 2, E-08036 Barcelona, Catalonia, Spain

[3] ICREA, Barcelona 08010, Catalonia, Spain

来源：

NATURE REVIEWS GENETICS | 2012年 / 13卷 / 10期

基金：

欧洲研究理事会;

关键词：

CPG ISLAND HYPERMETHYLATION; SUBEROYLANILIDE HYDROXAMIC ACID; HISTONE DEACETYLASE INHIBITOR; POLYMERASE-CHAIN-REACTION; PROSTATE-CANCER PATIENTS; PROMOTER HYPERMETHYLATION; HIGH-THROUGHPUT; COLORECTAL-CANCER; EPIGENETIC MODIFICATIONS; GSTP1; METHYLATION;

D O I：

10.1038/nrg3270

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Knowledge of epigenetic alterations in disease is rapidly increasing owing to the development of genome-wide techniques for their identification. The ever-growing number of genes that show epigenetic alterations in disease emphasizes the crucial role of these epigenetic alterations - particularly DNA methylation - for future diagnosis, prognosis and prediction of response to therapies. This Review focuses on epigenetic profiling, which has started to be of clinical value in cancer and may in the future be extended to other diseases, such as neurological and autoimmune disorders.

引用

页码：679 / 692

页数：14

共 139 条

[1] BLUEPRINT to decode the epigenetic signature written in blood [J].

Adams, David ;

Altucci, Lucia ;

Antonarakis, Stylianos E. ;

Ballesteros, Juan ;

Beck, Stephan ;

Bird, Adrian ;

Bock, Christoph ;

Boehm, Bernhard ;

Campo, Elias ;

Caricasole, Andrea ;

Dahl, Fredrik ;

Dermitzakis, Emmanouil T. ;

Enver, Tariq ;

Esteller, Manel ;

Estivill, Xavier ;

Ferguson-Smith, Anne ;

Fitzgibbon, Jude ;

Flicek, Paul ;

Giehl, Claudia ;

Graf, Thomas ;

Grosveld, Frank ;

Guigo, Roderic ;

Gut, Ivo ;

Helin, Kristian ;

Jarvius, Jonas ;

Kueppers, Ralf ;

Lehrach, Hans ;

Lengauer, Thomas ;

Lernmark, Ake ;

Leslie, David ;

Loeffler, Markus ;

Macintyre, Elizabeth ;

Mai, Antonello ;

Martens, Joost H. A. ;

Minucci, Saverio ;

Ouwehand, Willem H. ;

Pelicci, Pier Giuseppe ;

Pendeville, Helene ;

Porse, Bo ;

Rakyan, Vardhman ;

Reik, Wolf ;

Schrappe, Martin ;

Schuebeler, Dirk ;

Seifert, Martin ;

Siebert, Reiner ;

Simmons, David ;

Soranzo, Nicole ;

Spicuglia, Salvatore ;

Stratton, Michael ;

Stunnenberg, Hendrik G. .

NATURE BIOTECHNOLOGY, 2012, 30 (03) :224-226

[2] Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer [J].

Agrelo, Ruben ;

Cheng, Wen-Hsing ;

Setien, Fernando ;

Ropero, Santiago ;

Espada, Jesus ;

Fraga, Mario F. ;

Herranz, Michel ;

Paz, Maria F. ;

Sanchez-Cespedes, Montserrat ;

Artiga, Maria Jesus ;

Guerrero, David ;

Castells, Antoni ;

von Kobbe, Cayetano ;

Bohr, Vilheirn A. ;

Esteller, Manel .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (23) :8822-8827

[3] Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas [J].

Ahlquist, David A. ;

Zou, Hongzhi ;

Domanico, Michael ;

Mahoney, Douglas W. ;

Yab, Tracy C. ;

Taylor, William R. ;

Butz, Malinda L. ;

Thibodeau, Stephen N. ;

Rabeneck, Linda ;

Paszat, Lawrence F. ;

Kinzler, Kenneth W. ;

Vogelstein, Bert ;

Bjerregaard, Niels Chr. ;

Laurberg, Soren ;

Sorensen, Henrik Toft ;

Berger, Barry M. ;

Lidgard, Graham P. .

GASTROENTEROLOGY, 2012, 142 (02) :248-256

[4] The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer [J].

Ai, Lingbao ;

Kim, Wan-Ju ;

Demircan, Berna ;

Dyer, Lisa M. ;

Bray, Kevin J. ;

Skehan, Ryan R. ;

Massoll, Nicole A. ;

Brown, Kevin D. .

CARCINOGENESIS, 2008, 29 (03) :510-518

[5] Tumour and serum MGMT promoter methylation and protein expression in glioblastoma patients [J].

Balana, Carmen ;

Carrato, Cristina ;

Luis Ramirez, Jose ;

Felipe Cardona, Andres ;

Berdiel, Mireia ;

Javier Sanchez, Jose ;

Taron, Miquel ;

Hostalot, Cristina ;

Musulen, Eva ;

Ariza, Aurelio ;

Rosell, Rafael .

CLINICAL & TRANSLATIONAL ONCOLOGY, 2011, 13 (09) :677-685

[6] Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells [J].

Ball, Madeleine P. ;

Li, Jin Billy ;

Gao, Yuan ;

Lee, Je-Hyuk ;

LeProust, Emily M. ;

Park, In-Hyun ;

Xie, Bin ;

Daley, George Q. ;

Church, George M. .

NATURE BIOTECHNOLOGY, 2009, 27 (04) :361-368

[7] Diagnostic and prognostic information in prostate cancer with the help of a small set of hypermethylated gene loci [J].

Bastian, PJ ;

Ellinger, J ;

Wellmann, A ;

Wernert, N ;

Heukamp, LC ;

Müller, SC ;

von Ruecker, A .

CLINICAL CANCER RESEARCH, 2005, 11 (11) :4097-4106

[8] A decade of exploring the cancer epigenome - biological and translational implications [J].

Baylin, Stephen B. ;

Jones, Peter A. .

NATURE REVIEWS CANCER, 2011, 11 (10) :726-734

[9] Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry [J].

Berdasco, Maria ;

Esteller, Manel .

DEVELOPMENTAL CELL, 2010, 19 (05) :698-711

[10] Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains [J].

Berman, Benjamin P. ;

Weisenberger, Daniel J. ;

Aman, Joseph F. ;

Hinoue, Toshinori ;

Ramjan, Zachary ;

Liu, Yaping ;

Noushmehr, Houtan ;

Lange, Christopher P. E. ;

van Dijk, Cornelis M. ;

Tollenaar, Rob A. E. M. ;

Van den Berg, David ;

Laird, Peter W. .

NATURE GENETICS, 2012, 44 (01) :40-U62

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