Synthesis of 5-methylamino-2′-deoxyuridine derivatives

被引：6

作者：

Catalanotti, B ^{[1
]}

Galeone, A ^{[1
]}

Mayol, L ^{[1
]}

Oliviero, G ^{[1
]}

Rigano, D ^{[1
]}

Varra, N ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2001年 / 20卷 / 10-11期

关键词：

D O I：

10.1081/NCN-100107194

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reductive amination of 3,5'-O-(tetraisopropyldisilyloxane-1,3-diyl)2'-deoxy-5-formyluridine with several aliphatic and aromatic amines, in various solvents, is described. In the case of aliphatic amines, the expected C-5 substituted methylamino pyrimidine nucleosides are formed along with by-products deriving from opening of the pyrimidine ring. Relative amounts of the by-products depend upon the polarity of the solvent employed.

引用

页码：1831 / 1841

页数：11

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