Synthesis of 5-methylamino-2′-deoxyuridine derivatives

被引:6
作者
Catalanotti, B [1 ]
Galeone, A [1 ]
Mayol, L [1 ]
Oliviero, G [1 ]
Rigano, D [1 ]
Varra, N [1 ]
机构
[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy
关键词
D O I
10.1081/NCN-100107194
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Reductive amination of 3,5'-O-(tetraisopropyldisilyloxane-1,3-diyl)2'-deoxy-5-formyluridine with several aliphatic and aromatic amines, in various solvents, is described. In the case of aliphatic amines, the expected C-5 substituted methylamino pyrimidine nucleosides are formed along with by-products deriving from opening of the pyrimidine ring. Relative amounts of the by-products depend upon the polarity of the solvent employed.
引用
收藏
页码:1831 / 1841
页数:11
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