Catalytic promiscuity and the divergent evolution of DNA repair enzymes

被引：106

作者：

O'Brien, PJ ^{[1
]}

机构：

[1] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA

来源：

CHEMICAL REVIEWS | 2006年 / 106卷 / 02期

关键词：

D O I：

10.1021/cr040481v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review discusses the known evolutionary relationships among DNA repair enzymes and between DNA repair enzymes and other cellular enzymes, focusing on the divergence of enzymatic function. Discussions include: overview of catalytic promiscuity and the evolutionary diversification of enzymes; chemical landscape for DNA damage and repair; overview of DNA repair pathways; examples of DNA repair enzymes that exhibit catalytic promiscuity; mechanistically diverse DNA repair enzyme superfamilies; and changes in substrate and reaction specificity of DNA repair enzymes.

引用

页码：720 / 752

页数：33

共 332 条

[1] Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA [J].

Aas, PA ;

Otterlei, M ;

Falnes, PO ;

Vågbo, CB ;

Skorpen, F ;

Akbari, M ;

Sundheim, O ;

Bjorås, M ;

Slupphaug, G ;

Seeberg, E ;

Krokan, HE .

NATURE, 2003, 421 (6925) :859-863

[2] Base excision and DNA binding activities of human alkyladenine DNA glycosylase are sensitive to the base paired with a lesion [J].

Abner, CW ;

Lau, AY ;

Ellenberger, T ;

Bloom, LB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (16) :13379-13387

[3] The 'evolvability' of promiscuous protein functions [J].

Aharoni, A ;

Gaidukov, L ;

Khersonsky, O ;

Gould, SM ;

Roodveldt, C ;

Tawfik, DS .

NATURE GENETICS, 2005, 37 (01) :73-76

[4] Phosphoryl group transfer: evolution of a catalytic scaffold [J].

Allen, KN ;

Dunaway-Mariano, D .

TRENDS IN BIOCHEMICAL SCIENCES, 2004, 29 (09) :495-503

[5] SCOP database in 2004: refinements integrate structure and sequence family data [J].

Andreeva, A ;

Howorth, D ;

Brenner, SE ;

Hubbard, TJP ;

Chothia, C ;

Murzin, AG .

NUCLEIC ACIDS RESEARCH, 2004, 32 :D226-D229

[6] Standard free energy for the hydrolysis of adenylylated T4 DNA ligase and the apparent pKa of lysine 159 [J].

Arabshahi, A ;

Frey, PA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (13) :8586-8588

[7] The catalytic domain of the P-type ATPase has the haloacid dehalogenase fold [J].

Aravind, L ;

Galperin, MY ;

Koonin, EV .

TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (04) :127-129

[8] Conserved domains in DNA repair proteins and evolution of repair systems [J].

Aravind, L ;

Walker, DR ;

Koonin, EV .

NUCLEIC ACIDS RESEARCH, 1999, 27 (05) :1223-1242

[9]

Aravind L, 1999, In Silico Biol, V1, P69

[10]

Aravind L, 2001, GENOME BIOL, V2

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